Cnidium monnieri Extract
- Latin Name: Cnidium monnieri (L.) Cuss.
- Synonyms: Conidium Fruit, Monnier's Snowparsley, She Chuang Zi,
- Part of Used: Fruit(seed)
- Specifications: 10:1 TLC (Water-soluble), osthole 10%-98%
- Appearance: Light yellow brown fine powder
- Application: Medicine, food additive, dietary supplement，Cosmetics
Email: info@nutragreen.co.uk
| Product name |
Cnidium monnieri Extract |
| Latin Name |
Cnidium monnieri (L.) Cuss. |
| Active ingredients |
Osthole |
| synonyms |
Conidium Fruit, Monnier's Snowparsley, She Chuang Zi |
| Appearance |
Light yellow brown fine powder |
| Part used |
Fruit(seed) |
| Specification |
10:1 TLC (Water-soluble), Osthole |
| Dosage |
1500-2000mg daily |
| Main benefits |
Antioxidant, anticancer, liver protection,
anti-diabetes |
| Applied industries |
Medicine, food additive, dietary supplement，Cosmetics |
What is Cnidium monnieri Extract?
Cnidium
Monnier is a Chinese herb that has been used for centuries in Traditional
Chinese Medicine (TCM) as an herbal anti-itch lotion and remedy for a variety
of skin ailments and as a reproductive aid and aphrodisiac that increases
sexual desire in both men and
women. Today, we are told that it assists
the body in producing nitric oxide, which relaxes smooth muscles and works to
encourage healthy sexual function, and it has been used to treat male sexual
dysfunction. It also shows promise in
the areas of osteoporosis, allergies and carcinoma research. it is also said to
be 'anti-aging' and to 'build up strength', highly vague claims.
Chemical constituents of Cnidium monnieri Extract
Coumarin compounds such as Osthole and
Imperatorin as well as Xanthotoxin (Methoxsalen). Isopimpinellin, and Bergapten
have also been identified Hydrated berries of Cnidii have concentrations around
1.67-2.88% osthole.
Osthole is commonly seen as the primary active ingredient due to it being the most prominent courmarin derivative in Cnidium Monnieri,and is a coumarin derivative compound. It's true chemical name is 7-methoxy-8{3-methylpent 2-enyl}coumarin.The fruits tend to be used in Traditional Chinese Medicine, but the seeds of Cnidium Monnieri contains these bioactives as well.
Benefits of taking Cnidium monnieri Extract
supplements:
1. Skin Health
Cnidii Fructus (fruits of Cnidium) have
traditionally been used orally as an anti-allergic substance; when testing a
variety of traditional herbs (n=33 in total, 6 found to be effective) touted to
suppress skin irritation, Cnidium appears to be the most effective in
inhibiting substance-P induced itching behaviour in mice.
Through the centuries, traditional Chinese medicine used cnidium to
treat skin conditions. Today, it is a popular ingredient in Chinese skin
creams, ointments and lotions.
The herb’s antibacterial, antifungal and antipruritic properties make cnidium ideal for skin treatments. Holistic practitioners use the extract for numerous skin conditions including dermatitis, eczema, ringworm, rash and itching.
2. Men's
Health
>Skeletal
Muscle
Osthole has been implicated in increasing AMPK-mediated glucose uptake into myocytes (both C2C12 and L6) in dose and time dependent manners, although tested mostly at 12.5-50uM and also affects hepatocytes to a less potent extent. Incubation of muscle cells with 12.5uM and 50uM increases glucose uptake via GLUT4 translocation induced by AMPK by 1.6 and 2-fold; respectively. These effects on AMPK may be due to shifting the AMP:ATP ratio, as osthole seems to deplete ATP and elevate relative amounts of AMP, which is known to be the lead inducer of skeletal muscle AMPK.Osthole was known to be anti-glycemic in vivo at 50mg/kg prior to the discovery of AMPK interactions, and was mimicked in streptozotocin-induced diabetic mice at 100mg/kg osthole orally for 8 weeks.
Osthole apparently may also phosphorylate
(activate) Akt, and the downstream proteins of AS160 and GSK3; another
mechanism by which GLUT4 may be increased.
>
Erections
Cnidium Monnieri is, supposedly, a
frequently prescribed herb among Chinese Medicine practitioners for male
impotence. It has traditionally been used for treatment of male erections (or
the lack thereof) alongside Epimedium Sagittatum (related to Horny Goat Weed)
and the plant Semen Cuscutae.
When examined in vitro on corpus cavernosum
(penis wall) muscles, the bioactive ingredient Osthole appears to be able to
cause muscular relaxation (pro-erectile) in a dose-dependent manner. The
mechanism may be via phosphodiesterase inhibition, as osthole appears to
potentiate cGMP induced relaxation as well as nitric oxide. These effects are
common to all coumarins in Cnidium Monnieri, with Imperatorin being requiring
the lowest concentration to be effective.
There may also be central (brain) effects
as well, due to the ability of osthole to induce glutaminergic neurotransmission
(see Neurology section).
Not yet studied in humans, but has traditional usage of being an erection promoting herb in Traditional Chinese Medicine and appears to be active on both the penis tissues and the brain in similar manners to Viagra.
3.Liver
Interactions
>Fatty
Liver
Osthole is able to reduce fatty liver induced by Alcohol; in a study where mice were fed 52% of caloric intake as ethanol for 4 weeks and then given 10-40mg/kg Osthole for 6 weeks, Osthole was able to normalize alterations in CPT1A and CYP2E1 transcription rates (made abnormal with prolonged alcohol ingestion, and conducive to further fat buildup) and was able to decrease liver fat content in a rehabilitative manner.These effects are also seen when the same dose of osthole is co-ingested, and are attributed to anti-oxidant and anti-inflammatory mechansims, although Osthole does appear to induce PPARa activation which can then reduce DGAT and HMG-CoA activity; a shift towards lipid mobilization rather than storage. Minor dose-dependence is seen, with more Osthole exerting more protection but 10mg/kg seeming to be the most cost-effective dose.
Other
Bodybuilders take cnidium supplements to
increase energy and boost athletic performance. Because it improves
concentration and memory, the herb is sometimes used to prevent Alzheimer’s
disease and other dementias. It is also beneficial for the weak, brittle bones
of osteoporosis.
Side effects and safety of Cnidium monnieri Extract
Although there are no current definitive warnings listed with the use of Cnidium Monnier Herbal Supplement, it is not advisable for pregnant or nursing women to use this herb unless under the care of a physician.
Dosage of Cnidium monnieri Extract supplement:
Concerning oral supplements, practitioners recommend a standard dose between six and 15 grams. For skin treatments, where cnidium is found in creams or ointments, the dose is irrelevant.
Nutragreen Biotechnology Co., Ltd, a brand of Shanghai Lvshang Biotech Co., Ltd, is a GMP compliant and FDA registered manufacturer and supplier of raw materials of plant extracts, botanicals, herbs, especially Tradtional Chinese herbs. Cnidium monnieri Extract is one of our most competitive ingredients with various specifications and stocks available all year round. You may leave a message below for more detailed information.
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