Muira puama extract

• Product Detail

Product name	Muira puama poextract
Latin Name	Muira puama
Active ingredients	Alkaloid
synonyms	Phyllanthus niruri include chanca piedra in Spanish, bhumyamalaki , sampa-sampalukan , quebra-pedra. nalla usiri in Telugu, keezha nelli , nela nelli,keezhar nelli, dukong anak, dukong-dukong anak, amin buah, rami buah, turi hutan, bhuiaonla, meniran hijau, Obukoko , Nli-ndulie etc.
Appearance	Brown-yellow fine powder
Part used	Bark
Specification	4:1 TLC/10:1 TLC/20:1 TLC/40:1 TLC
Main benefits	bladder infections, colds diabetes,hepatitis B,kidney disorders
Applied industries	Medicine, food additive, dietary supplement, sports nutrition

 

What is Muira puama extract?

Ptychopetalum is a genus of two species of flowering plants in the family Olacaceae (not to be confused with the Oleaceae or olive family), native to the Amazon rainforest. The indigenous name for the genus is Muira Puama, "potency wood".

Muira puama is used for preventing sexual disorders and to increase interest in sexual activity (as an aphrodisiac). It is also used for upset stomach, menstrual disorders, joint pain (rheumatism), and paralysis caused by poliomyelitis; and as a general tonic and an appetite stimulant.

Chemical constituents of Muira puama extract 

  Muira puama powder extract contains long-chain fatty acids, plant sterols, coumarin, lupeol, and the alkaloid muirapuamine. There is a second almost identical species, Ptychopetalum uncinatum, which is sometimes used as a substitute with the only noticeable difference being a lower concentration of the chemical lupeol.

Benefits of taking Muira puama extract supplements:

Muira puama is so popular that it is used around the world in herbal medicine. For instance, in Brazil and South America, it is used as a neuromuscular tonic, for asthenia, paralysis, chronic rheumatism, sexual impotence, grippe, ataxia, and central nervous system disorders. It is also considered to help boost physical performance. In England, it is still listed in the British Herbal Pharmacopoeia, where it is recommended for the treatment of dysentery and impotence. In the US, it is gaining more popularity and is considered by some to be the "new" yohimbe, but with considerably fewer negative side effects.

1) Muira puama powder extract and erectile dysfunction

>Effect of ginger, Paullinia cupana, muira puama and l- citrulline, singly or in combination, on modulation of the inducible nitric oxide- NO-cGMP pathway in rat penile smooth muscle cells.

Ferrini MG1, Garcia E2, Abraham A2, Artaza JN3, Nguyen S2, Rajfer J4.

Abstract

INTRODUCTION:

COMP-4 is a natural compound-based dietary supplement consisting of the combination of ginger, Paullinia cupana, muira puama and l-citrulline, which when given long-term has been shown in the aged rat to a) upregulate iNOS in the penile smooth muscle cells (SMC), b) reverse the corporal SMC apoptosis and fibrosis associated with corporal veno-occlusive dysfunction (CVOD), and c) improve resulting erectile function. To elucidate the mechanism of how COMP-4 and its individual components modulate the iNOS-cGMP pathway, an in vitro study was conducted using a rat corporal primary SMC culture to determine its effect on NOS, soluble guanylate cyclase (sGC), cGMP and the phosphodiesterase 5 enzyme (PDE5).

MATERIALS AND METHODS:

Primary SMC cultures using the explant technique were initiated by cutting small pieces of corporal tissue from 8 week old Sprague-Dawley rats. The SMC were grown in Dulbecco media with 20% fetal calf serum. The SMC were then incubated with or without COMP-4 (0.69 mg/ml) or its ingredients alone (ginger: 0.225 mg/ml; muira puama, Paullinia cupana and l-citrulline each at 0.9 mg/ml) for up to 24 h mRNA and protein were extracted and used for the determination of NOS, sGC and PDE5 content. cGMP content was determined by ELISA. L-NIL (4 μM) was used as an inhibitor of iNOS activity.

RESULTS:

Compared to the control values, COMP-4 upregulated expression of cGMP by 85%, induced a 42 fold increase in sGC as well as a 15 fold increase in both iNOS protein and mRNA content while it decreased both PDE5 mRNA and protein content each by about 50%. L-NIL completely inhibited the effect of COMP-4 on cGMP production. When compared with each of the individual four components of COMP-4, it appears that COMP-4 itself had the most profound effect in modulating each one the specific steps within the iNOS-cGMP pathway.

CONCLUSIONS:

This in vitro study demonstrates that COMP-4 is capable of activating the endogenous cellular iNOS-cGMP pathway within the CSM cells, which is theorized to be responsible for reducing the fibrosis and apoptosis as well as the CVOD observed in the aging rat penis. Further studies will be necessary in order to determine whether supplementation of COMP-4 on a daily basis may be beneficial in halting or reversing this aging related erectile dysfunction in the clinical setting.

Side effects and safety of Muira puama extract 

Has not yet been reported that he has serious side effects.