Ursolic
acid is a pentacyclic triterpene acid, used in cosmetics that is also capable
of inhibiting various cancer cell types by inhibiting the STAT3 activation pathway,
one of which includes human fibrosarcoma by reducing expression of matrix
metalloproteinase-9 via glucocorticoid receptors. It may also decrease
proliferation of cancer cells and induce apoptosis.[4] Ursolic acid has also
been shown to inhibit JNK expression and IL-2 activation of JURKAT leukemic T
Cells leading to the reduction in proliferation and T cell activation. Ursolic
acid is present in many plants, including apples, basil, bilberries,
cranberries, elder flower, peppermint, rosemary, lavender, oregano, thyme,
hawthorn, and prunes. Bearberry contain large quantities of ursolic acid and
related compounds.
Ursolic
acid can serve as a starting material for synthesis of more potent bioactive
derivatives, such as antitumor agents. It has been found to reduce muscle
atrophy and to stimulate muscle growth in mice. Ursolic acid has potential use
as a cardioprotective compound.
Ursolic
acid has medicinally action, both topically and internally. Ursolic acid is
used in many cosmetic preparations for its anti-inflammatory, antitumor and
antimicrobial properties.
Ursolic
acid has antibacterial and antifungal activity. Tests have shown that Ursolic
acid inhibits the growth of Candida albicans and Microsporium lenosum.
Ursolic acid has anti-inflammatory properties and is used in ointments to treat
burns.
Topical
application of ursolic acid inhibited TPA-induced initiation and promotion of
tumor growth.
Ursolic
Acid is found in apple peel first. With the value of usolic acid enhance, the
better usolic acid have found in the bearberry.
Bearberries
are three species of dwarf shrubs in the genus Arctostaphylos. Unlike the other
species of Arctostaphylos, they are adapted to Arctic and Subarctic climates,
and have a circumpolar distribution in northern North America, Asia and Europe,
one with a small highly disjunctive population in Central America.
Nutra Green is a well established company with over 10
years supplying experienced for Ursolic acid. Except the
ursolic acid from bearberry, Nutra Green also extract the Ursolic acid from Loquat Leaf, Basil,cranberries, and Bilberry. So they always supply the best product to customers depend on
different customers’ requirement. In the 10 yearing business, Nutra Green has
won a lot of praise and affirmation. The Nutra Green product Raspberry Extract
contains Raspberry Ketone from 15% to 98%. It’s really good chance for enhance
everybody’s life quality