Coprinus Comatus Extract Polysaccharides

• Product Detail

Product name	Coprinus Comatus Extract
Latin Name	Coprinus Comatus
Active ingredients	Polysaccharides
synonyms	Coprin chevelu, Gyapjas tintagomba, Schopftintling, Shaggy Ink cap, Shaggy Mane, C. comatus
Appearance	Brown yellow fine powder
Part used	Fruit Body
Specification	Polysaccharides 30%
Dosage
Main benefits	Antioxidant, anticancer, Anti-tumor, anti-diabetes
Applied industries	Medicine, food additive, dietary supplement

What is Coprinus Comatus?

Coprinus comatus, the shaggy ink cap, lawyer's wig, shaggy parasol or shaggy mane, is a common fungus often seen growing on lawns, along gravel roads and waste areas. The young fruit bodies first appear as white cylinders emerging from the ground, then the bell-shaped caps open out. The caps are white, and covered with scales—this is the origin of the common names of the fungus. The gills beneath the cap are white, then pink, then turn black and secrete a black liquid filled with spores (hence the “ink cap”name). This mushroom is unusual because it will turn black and dissolve itself in a matter of hours after being picked or depositing spores. When young it is an excellent edible mushroom provided that it is eaten soon after being collected (it keeps very badly because of the autodigestion of its gills and cap).

Chemical constituents of Coprinus Comatus Extract

A study of flavor compounds present in C. comatus revealed a variety of compounds in the water extract from the fruit body, including:

§  3-octanone

§  3-octanol

§  1-octen-3-ol

§  1-octanol

§  2-methyl-2-penten-4-olide

§  1-dodecanol

§  caprylic acid

§  5’-GMP

§  glutamic acid

§  n-butyric acid and isobutyric acids (putatively).

Interestingly, a mixture of 37 compounds found in the extract had a stronger flavor than the natural extract, suggesting the presence of compounds that mask or lessen the flavor intensity.

Use most is to extract the polysaccharide in health care applications.

Benefits of taking Coprinus Comatus Extract supplements:

 Anti-tumor activity

The water extract of Coprinus comatus was recently identified as containing potent antitumor compounds for breast cancer. Because breast cancer is the most commonly diagnosed cancer among women worldwide, and because there is no effective therapy for estrogen-independent (ER-) breast cancer, these findings are highly significant. The antitumor potential of the water extract was shown to manifest itself in three ways:

1) it inhibited the growth of both ER+ and ER- breast cancer cells

2) it induced both ER+ and ER- cells to die (apoptosis)

3) it inhibited tumor colony formation in vitro

An alkaline protein named y3, purified from fruiting bodies of C. comatus, was shown to inhibit a gastric cancer cell line with an IC50 of 12 µg/mL.Serum lysozyme activity is used as a general indicator of immune system fitness. In addition to breaking down polysaccharides found in bacterial cell walls, lysozyme can also bind to the surface of some invading bacteria and make it easier for white blood cells to engulf them. Chinese research has shown that polysaccharide solutions extracted from C. comatus and given to mice had the ability to increase serum lysozyme activity.

Hypoglycemic effects

A number of studies have demonstrated that consumption of C. comatus can help regulate blood glucose concentrations. Feeding mice a diet containing powdered dried fruit bodies of C. comatus (one-third of their food intake, by weight) reduced their plasma glucose concentrations and improved intraperitoneal glucose tolerance. Also, body weight gain was halted, even though total energy intake was not substantially reduced. Plasma glucose was marginally lowered 10 hours after intragastric administration of dried C. comatus (3.6 g/kg body weight). The results suggest a slowly generated, mild hypoglycemic effect of C. comatus in normal mice, accompanied by metabolic effects capable of interrupting body weight gain

In other studies, the hypoglycemic activity of fermented mushroom of Coprinus comatus rich in vanadium was investigated. Vanadium salts have insulin-mimetic activity, and vanadium compounds are being studied as potentially orally active replacements for insulin. Vanadium salts mimic most of the effects of insulin in vitro and also induce normoglycemia and improve glucose homeostasis in insulin-deficient and insulin-resistant diabetic rodents in vivo. One study showed that Coprinus comatusfermentation liquid and sodium vanadate inhibited ascension of blood glucose in mice. The blood glucose and the HbA1c (glycosylated hemoglobin – used to measure plasma glucose concentration) of the mice were analyzed. Also, the sugar tolerance of the normal mice was also determined. After the mice were given the vanadium-rich mushroom mycelia, the blood glucose and the HbA1c of hyperglycemic mice decreased, ascension of blood glucose induced by adrenalin was inhibited and the sugar tolerance of the normal mice was improved. Also, the body weight of the alloxan-induced hyperglycemic mice was increased gradually. In the fermented mushroom of C. comatus, vanadium at lower doses in combination with C. comatus, induced significant decreases of the blood glucose and HbA1c levels in hyperglycemic mice

Polysaccharides extracted from the mycelial culture of C. comatus and administered intraperitoneally into white mice at a dosage of 300 mg/kg inhibited the growth of Sarcoma 180 and Ehrlich solid cancers by 100% and 90%, respectively.

Antioxidant activity

Over fifty years ago, shaggy-manes were found to contain ergothioneine, a thiol compound with antioxidant properties.

Antimicrobial activity

A Russian study has revealed that various strains of the genus (formerly known as) Coprinus, including C. Comatus.

Side effects and safety of Coprinus Comatus Extract

Contemporary science and medical clinical tests have proved that Mushroom Polysaccharide is non-toxic and no side effects. It can be used freely. In general, Coprinus Comatus Extract i can be used for food directly, also can be used for health care.

Dosage of Coprinus Comatus Extract supplement:

Consult your physician if you have any questions about the proper use of Coprinus Comatus Extract supplements.

There are some other Mushroom extract Polysaccharides Series available from Nutragreen biotechnology such as

Mushroomextract Polysaccharides Series	Specification
Reishi Mushroom Extract	Reishi Polysaccharides 10%-60%
Cordyceps Extract	Polysaccharides 10%-40%
Coriolus Versicolor Extract	Polysaccharides 10%-40%
Maitake Extract	Polysaccharides 10%-40%
Poria Extract	Polysaccharides 10%-30%
Shiitake Extract	Polysaccharides 10%-40%
Hericium erinaceus Extract	Polysaccharides 10%-30%
Coprinus Comatus Extract	Polysaccharides 10%-30%
Oyster Mushroom Extract	Polysaccharides 10%-30%
Chaga Extract	Polysaccharides 10%-30%
Polyporus umbellatus Extract	Polysaccharides 10%-30%
Agaricus Mushroom Extract	Polysaccharides 10%-30%