Echinacea Purpurea extract powder

• Product Detail

Product name	Echinacea Purpurea extract powder
Latin Name	Echinacea Purpurea
Active ingredients	Polyphenols, Cichoric Acid
synonyms	Brauneria purpurea (L.) Britt., Echinacea intermedia Lindl., E. purpurea (L.) Moench f., E. purpurea (L.) Moench var. arkansana Steyerm., E. speciosa Paxt., Rudbeckia purpurea L., R. hispida Hoffm., R. serotina Sweet
Appearance	Yellow Green fine powder
Part used	Aerial part
Specification	5:1 TLC/Polyphenols 4% UV
Dosage	250-500mg a daily
Main benefits	antisepsis,anti-inflammation,common cold
Applied industries	Medicine, food additive, dietary supplement

What is Echinacea Purpurea extract powder

Echinacea Purpurea Extract (EP, purple coneflower) have been used traditionally in North America for the treatment of various types of infections and wounds, and they have become very popular herbal medicines globally. Recent studies have revealed that certain standardized preparations contain potent and selective antiviral and antimicrobial activities. In addition, they display multiple immune-modulatory activities, comprising stimulation of certain immune functions such as phagocytic activity of macrophages and suppression of the proinflammatory responses of epithelial cells to viruses and bacteria, which are manifested as alterations in secretion of various cytokines and chemokines. These immune modulations result from upregulation or downregulation of the relevant genes and their transcription factors. All these bioactivities can be demonstrated at noncytotoxic concentrations of extract and appear to be due to multiple components rather than the individual chemical compounds that characterize Echinacea extracts. Potential applications of the bioactive extracts may go beyond their traditional uses.

Echinacea is a flower native to North America mostly found in the Midwest United States.  The Echinacea plant grows in the United States from the Midwest to the prairies of Pennsylvania.  It is a plant that grows 1-2 feet tall and looks spiny.  Echinacea is a common name for three species of daisy plants called: Echinacea angustifolia, Echinacea pallida, and Echinacea purpurea.  The plants are commonly known as narrow-leaved purple coneflower, pale purple coneflower, and purple coneflower respectively.  Echinacea angustifolia has other common names such as hedgehog coneflower, black sampson, sampson root, and rudbeckia.  Echinacea is used as an herbal medication.  The medication is obtained from the roots, stems, and leaves of Echinacea purpurea.  Dried rhisomes and roots are used from Echinacea angustifolia and Echinacea pallida.  The rhizomes and roots are used most often in preparations of medicine.  In some medicinal preparations the whole Echinacea plant is used.  The Echinacea plant has been over harvested and is now being considered for endangered species status.

History of Echinacea                

Echinacea has been used for hundreds of years as a stimulant, anti-viral, and bacterial aid.  Native Americans, mostly Plains Indians used Echinacea for medicinal purposes.  The Native Americans used Echinacea as a herbal remedy for treating and preventing colds, flu, and infections.  It was thought by the Native Americans that the herb possessed antibacterial, antiviral, and antifungal properties.  Some examples of Echinacea's uses by Plains Indians is it was used as an antiseptic, analgesic, treat poisonous insect and snakebites, toothaches, sore throat, wounds, and infectious diseases such as smallpox, mumps, and measles.  Echinacea was also used by the Cheyenne, Choctaw, Dakota, Sioux, and many more tribes.  When settlers came to the New World they adopted Echinacea uses and it has been used in America ever since.  Echinacea gained more popularity in the United States in the 1800's.  Many doctors widely prescribed Echinacea as natural remedy for infections.  Also, Echinacea became known in Europe around 1895.  In Europe, Echinacea preparations are used mostly to stimulate the immune system and help prevent common cold infections affecting nose and throat (http://www.supplementwatch.com/supatoz/supplement.asp?supplementId=106).  Echinacea products have the greatest popularity in Germany, where they are approved for treatment of respiratory and urinary infections and for external treatment of wounds.

Chemical constituents Echinacea Purpurea extract powder

The main active ingredient is polyphenols, caffeic acid derivatives, and polysaccharides.

The volatile oil contains, among other compounds, borneol, bornyl acetate, pentadeca-8-(Z)-en-2-one, germacrene D, caryophyllene, and caryophyllene epoxide.

How does work Echinacea Purpurea extract powder

Echinacea stimulates the overall activity of the cells responsible for fighting all kinds of infection. Unlike antibiotics, which directly attack bacteria, echinacea makes our own immune cells more efficient at attacking bacteria, viruses and abnormal cells, including cancer cells. It increases the number and activity of immune system cells including anti-tumor cells, promotes T-cell activation, stimulates new tissue growth for wound healing and reduces inflammation in arthritis and inflammatory skin conditions.

The most consistently proven effect of echinacea is in stimulating phagocytosis (the consumption of invading organisms by white blood cells and lymphocytes). Extracts of echinacea can increase phagocytosis by 20-40%.

Echinacea also stimulates the production of interferon as well as other important products of the immune system, including "Tumor Necrosis Factor", which is important to the body's response against cancer.

One of the most significant medicinal properties of echinacea purpurea is its ability to stimulate the immune system by encouraging the production of leukocytes, the medical term for white blood cells. The immune system is responsible for keeping the body healthy by helping it fight off infection, disease and even the early development of cancer, but it often needs to be stimulated and strengthened in order to perform its job efficiently. These special white blood cells are essential in this system of defense to seek out and destroy organisms such as harmful bacteria and viruses. This is why echinacea purpurea is said to be antiviral and anti-inflammatory.

External uses include promotion of wound healing and treatment of inflammatory skin conditions.

Benefits of taking Echinacea Purpurea extract powder

supplements:

1.immune stimulation

Inulin: granulocytes and by increasing the number of white blood cells play a role in enhancing the monocyte chemotaxis and neutral to produce viral lysis.

Polysaccharides: T lymphocytes and macrophages hydrocarbon receptor immune stimulation, can increase the phagocytic activity of macrophages and stimulate macrophages increased tumor necrosis factor, interferon, interleukin count the number of energy destroy tumor cells.

Alkyl amines and caffeic acid derivatives: lipophilic alkyl amines can increase macrophage phagocytosis.

Echinacea: increase non-specific T cells to produce interferon, and promote the secretion of lymphocytes, T-helper cells decrease, reducing the T-helper cells and inhibition of factor ratio.

>Applications of the phytomedicine Echinacea purpurea (Purple Coneflower) in infectious diseases.(Source-Department of Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada)

Extracts of Echinacea purpurea (EP, purple coneflower) have been used traditionally in North America for the treatment of various types of infections and wounds, and they have become very popular herbal medicines globally. Recent studies have revealed that certain standardized preparations contain potent and selective antiviral and antimicrobial activities. In addition, they display multiple immune-modulatory activities, comprising stimulation of certain immune functions such as phagocytic activity of macrophages and suppression of the proinflammatory responses of epithelial cells to viruses and bacteria, which are manifested as alterations in secretion of various cytokines and chemokines. These immune modulations result from upregulation or downregulation of the relevant genes and their transcription factors. All these bioactivities can be demonstrated at noncytotoxic concentrations of extract and appear to be due to multiple components rather than the individual chemical compounds that characterize Echinacea extracts. Potential applications of the bioactive extracts may go beyond their traditional uses.

Selective cytokine-inducing effects of low dose Echinacea.(Helvet Group, Moscow Re-gion, Dolgoprudnyi, Russia.)

Abstract

Echinacea purpurea is a widely used plant immunomodulator with a selective immunomodulatory effect depending on the dilution of the initial preparation. In low doses, it causes selective induction of pro- and anti-inflammatory cytokines. The results recommend this preparation in a wide range of concentrations for adequate correction of the immune system work aimed at restoring the Th1/Th2 balance in various diseases.

2.organizational renewal and anti-inflammatory effects

Inhibition of hyaluronidase, can stimulate the growth of fibroblasts with glucosamine synthesis of the enzyme, resulting in cortical ketones role in promoting the secretion of adrenal hormones. Polysaccharide have anti-inflammatory effect.

>Content of proinflammatory cytokine in patients with clinical remission of chronic herpes infection during immunocorrection.

Source

Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia.

The concentrations of cytokines (interleukin-1beta, interleukin-6, and interferon-gamma) in blood plasma from patients with remission of chronic herpes infection were measured during immunocorrective therapy. Our results indicate that immunocorrection is pathogenetically substantiated and immunologically effective. It was manifested in reduction of inflammation and activation of antiviral protection.

3 anti-bacterial effect

Echinacea glycosides and caffeic acid derivatives have weak antibacterial activity.

4 antiviral

Can inhibit influenza, herpes viruses and foaming, due to antiviral activity of hyaluronidase inhibition can impede viral cell surface receptors.

>Use of a standardized extract from Echinacea angustifolia (Polinacea) for the prevention of respiratory tract infections.(Velleja Research, Pontenure, Italy.)

Echinacea preparations are extensively used for the prevention and the management of the common cold. Despite this popularity, the clinical studies on Echinacea have produced mixed results, possibly in part because of the poor characterization of the extracts investigated and the use of different species and/or plant parts for the preparations investigated in the various trials. To address this issue, Polinacea, a highly standardized extract from a well-defined botanical source (roots of Echinacea angustifolia) with a specific phytochemical profile (presence of the complex polysaccharide IDN5405, the phenylethanoid echinacoside, and substantial lack of alkamides) was developed. We have studied whether Polinacea could enhance the immune response subsequent to the influenza vaccination, and whether the use of this preparation could translate into a decreased morbidity from influenza. The preliminary results were encouraging, and suggest

Scope of application of Echinacea Purpurea extract powder

Echinacea and it’s extracts used for general infection or trauma, cold or flu, rosary viruses, Candida throat, staph infections, urinary tract infections, pelvic inflammatory (PID), tonsil infection, upper respiratory tract infection, wound infection, toothache or oral infections, insect, animal or snake bites, blood poisoning, boils, abscesses, eczema and so on. Improve acute and chronic pharyngitis caused by sore throat, dry and burning, hoarseness; boost the immune system, prevent flu, shortening colds, relieve sore throat, with mild infections, colds, coughs, flu, and other upper respiratory tract symptoms . Promote protein synthesis and enzyme involved in the synthesis and immune-related aspects play an important role in both. Run support bone marrow, improve immunity. Effectively improve recurrent oral ulcers, respiratory and gastrointestinal infections and other symptoms.

Side effects and safety of Echinacea Purpurea extract powder

Use too much can lead to a low grade fever, sensitive crowd dermatitis may occur.

Overall, Echinacea is considered safe. It is well tolerated by most people. When taken as directed, little or no toxicity is associated with Echinacea use.  Echinacea may possibly be beneficial, in reducing duration and severity of symptoms.  Echinacea should not be used for auto-immune disorders such as tuberculosis and leucosis.  AIDS patients use of Echinacea is very controversial because not sure of its effects.  Other people that should not take Echinacea are those allergic to plants in the daisy family.  Prolonged use (more than eight weeks) is not recommended and may cause immune suppression or liver problems.  Echinacea should not be substituted for other medical treatments in very rapid infections.

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