Phyllanthus niruri extract pwoder-US Stock available

• Product Detail

Product name	Phyllanthus niruri extract pwoder
Latin Name	Phyllanthus nirurili
Active ingredients	Gallic acid
synonyms	Phyllanthus niruri include chanca piedra in Spanish, bhumyamalaki , sampa-sampalukan , quebra-pedra. nalla usiri in Telugu, keezha nelli , nela nelli,keezhar nelli, dukong anak, dukong-dukong anak, amin buah, rami buah, turi hutan, bhuiaonla, meniran hijau, Obukoko , Nli-ndulie etc.
Appearance	Brown-yellow fine powder
Part used	Herb
Specification	10:TLC,Gallic acid 1.5% HPLC, Gallic acid 5% HPLC, Gallic acid 15% HPLC
Main benefits	kidney stones, colds diabetes,hepatitis B,kidney disorders
Applied industries	Medicine, food additive, dietary supplement, sports nutrition

 

What is Phyllanthus niruri?

Phyllanthus niruri is a widespread tropical plant commonly found in coastal areas, known by the common names gale of the wind, stonebreaker or seed-under-leaf. It is a relative of the spurges, belonging to the Phyllanthus genus of Family Phyllanthaceae.

Phyllanthus niruri has been used in Ayurveda for problems of the stomach, genitourinary system, liver, kidney and spleen.

Phyllanthus niruri is a weed found in coastal areas. It’s also known as gale of the wind or stonebreaker. Its leaves and fruit are used as herbal medicine.

Phyllanthus niruri is known for protecting the liver. It may also combat kidney stones, hence the “stonebreaker” moniker

Chemical constituents of Phyllanthus niruri extract pwoder

The active phytochemicals, flavonoids, alkaloids, terpenoids, lignans, polyphenols, tannins, coumarins and saponins, have been identified from various parts of P. niruri. Extracts of this herb have been proven to have therapeutic effects in many clinical studies.

How does work Phyllanthus niruri extract pwoder?

Some of the most intriguing therapeutic properties include anti-hepatotoxic, anti-lithic, anti-hypertensive, anti-HIV and anti-hepatitis B. Therefore, studies relating to chemical characteristics and structural properties of the bioactive phytochemicals found in Phyllanthus niruri extract pwoder are very useful for further research on this plant as many of the phytochemicals have shown preclinical therapeutic efficacies for a wide range of human diseases, including HIV/AIDS and hepatitis B.

Benefits of taking Phyllanthus niruri extract pwoder supplements:

For hundreds of years Phyllanthus niruri has been used as an herbal remedy to kidney stones, viral infections, liver disorders, bacterial infections, and many other ailments. In more recent years, however, P. niruri has been shown in modern medicine to cure or treat multiple disorders.

1)  Liver Health

In laboratory research, scientists have found that certain species of Phyllanthus may help prevent liver damage. For instance, a 2012 study from Pharmaceutical Biology determined that extracts of Phyllanthus niruri extract pwoder, Phyllanthus emblica, and Phyllanthus indofischeri had high levels of liver-protecting activity.

>Phyllanthus Niruri Standardized Extract Alleviates the Progression of Non-Alcoholic Fatty Liver Disease and Decreases Atherosclerotic Risk in Sprague-Dawley Rats.

Abstract

Non-alcoholic fatty liver disease (NAFLD) is one of the major global health issues, strongly correlated with insulin resistance, obesity and oxidative stress. The current study aimed to evaluate anti-NAFLD effects of three different Phyllanthus niruri extract pwoder. NAFLD was induced in male Sprague-Dawley rats using a special high-fat diet (HFD). A 50% methanolic extract (50% ME) exhibited the highest inhibitory effect against NAFLD progression. It significantly reduced hepatomegaly (16%) and visceral fat weight (22%), decreased NAFLD score, prevented fibrosis, and reduced serum total cholesterol (TC) (48%), low-density lipoprotein (LDL) (65%), free fatty acids (FFAs) (25%), alanine aminotransferase (ALT) (45%), alkaline phosphatase (ALP) (38%), insulin concentration (67%), homeostatic model assessment of insulin resistance (HOMA-IR) (73%), serum atherogenic ratios TC/high-density lipoprotein (HDL) (29%), LDL/HDL (66%) and (TC-HDL)/HDL (64%), hepatic content of cholesterol (43%), triglyceride (29%) and malondialdehyde (MDA) (40%) compared to a non-treated HFD group. In vitro, 50% ME of Phyllanthus niruri extract pwoder inhibited α-glucosidase, pancreatic lipase enzymes and cholesterol micellization. It also had higher total phenolic and total flavonoid contents compared to other extracts. Ellagic acid and phyllanthin were identified as major compounds. These results suggest that P. niruri could be further developed as a novel natural hepatoprotective agent against NAFLD and atherosclerosis.

2)  antidiabetic and Phyllanthus niruri extract pwoder

>Investigation of antidiabetic potential of Phyllanthus niruri L. using assays for α-glucosidase, muscle glucose transport, liver glucose production, and adipogenesis.

Author information

1.Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100, Copenhagen, Denmark. Electronic

2.Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100, Copenhagen, Denmark.

3.Natural Health Products and Metabolic Diseases Laboratory, Department of Pharmacology, Université de Montréal, H3T 1J4, Montreal, QC, Canada; Department of Pharmacognosy, University of Beni-Suef, 62511, Beni-Suef, Egypt.

4.Natural Health Products and Metabolic Diseases Laboratory, Department of Pharmacology, Université de Montréal, H3T 1J4, Montreal, QC, Canada.

Abstract

Phyllanthus niruri is used in herbal medicine for treatment of diabetes. The objective of this study was to investigate the antidiabetic potential of P. niruri, using assays for α-glucosidase, muscle glucose transport, liver glucose production and adipogenesis. α-Glucosidase inhibitory activity was performed on aqueous and ethanolic Phyllanthus niruri extract pwoder. The aqueous and Phyllanthus niruri extract pwoder showed α-glucosidase inhibitory activity with IC50 values of 3.7 ± 1.1 and 6.3 ± 4.8 μg/mL, respectively. HR-bioassay/HPLC-HRMS and NMR analysis was used for identification of compounds. Corilagin (1) and repandusinic acid A (2) were identified as α-glucosidase inhibitors in the water extract of P. niruri with IC50 values of 0.9 ± 0.1 and 1.9 ± 0.02 μM, respectively. In in vitro cell-based bioassays, cells were treated for 18 h with maximal non-toxic concentrations of the ethanolic Phyllanthus niruri extract pwoder, which were determined by the lactate dehydrogenase cytotoxicity assay. The ethanolic Phyllanthus niruri extract pwoder was not able to reduce glucose-6-phosphatase activity. However, the extract increased deoxyglucose uptake in C2C12 muscle cells and enhanced adipogenesis in 3T3-L1 fat cells which has been reported for the first time. The present study demonstrated that P. niruri may thus have potential application for treatment and/or management of type 2 diabetes.

3) breast cancer cells and Phyllanthus niruri extract pwoder

>Suppression of ERK1/2 and hypoxia pathways by four Phyllanthus species inhibits metastasis of human breast cancer cells.

Abstract

Chemotherapies remain far from ideal due to drug resistance; therefore, novel chemotherapeutic agents with higher effectiveness are crucial. The extracts of four Phyllanthus species, namely Phyllanthus niruri, Phyllanthus urinaria, Phyllanthus watsonii, and Phyllanthus amarus, were shown to induce apoptosis and inhibit metastasis of breast carcinoma cells (MCF-7). The main objective of this study was to determine the pathways utilized by these four Phyllanthus species to exert anti-metastatic activities. A cancer 10-pathway reporter was used to investigate the pathways affected by the four Phyllanthus species. Results indicated that these Phyllanthus species suppressed breast carcinoma metastasis and proliferation by suppressing matrix metalloprotein 2 and 9 expression via inhibition of the extracellular signal-related kinase (ERK) pathway. Additionally, inhibition of hypoxia-inducible factor 1-α in the hypoxia pathway caused reduced vascular endothelial growth factor and inducible nitric oxide synthase expression, resulting in anti-angiogenic effects and eventually anti-metastasis. Two-dimensional gel electrophoresis identified numerous proteins suppressed by these Phyllanthus species, including invasion proteins, anti-apoptotic protein, protein-synthesis proteins, angiogenic and mobility proteins, and various glycolytic enzymes. Our results indicated that ERK and hypoxia pathways are the most likely targets of the four Phyllanthus species for the inhibition of MCF-7 metastasis.

Side effects and safety of Phyllanthus niruri extract pwoder

Tests were initially performed to determine the safety of the Phyllanthus niruri extract pwoder when administered orally, the acute toxicity test was performed following OECD-423 guidelines . Twenty-four healthy Sprague Dawley rats (12 males and 12 females) were randomly assigned equally into 3 groups labeled as vehicle 10% Tween 20 and two large doses 2 g/kg and 5 g/kg of the extract, respectively. Each rat was made to fast (no food but water) overnight prior to dosing. Food was withheld for another 3 to 4 hours after the dosing. The rats were closely observed for 30 min and at 2, 4, 24, and 48 h after the dosing to detect if there were any acute signs of clinical or toxicological symptoms. After 14 days the rats were sacrificed to measure serum biochemical and (liver and kidney) histological parameters by following the standard methods .

There were no mortality in the rats administered with the doses 2 g/kg and 5 g/kg of the Phyllanthus niruri extract pwoder. Physically, they appeared normal and no signs of changes were observed in their skins, furs, eyes, and mucus membranes and salivations. Tremor, sleep, and behavior patterns were similar to those of the vehicle treated-rats. Their food intakes were normal and neither diarrhea nor other digestional problems was noticed. Weight gains in these rats paralleed to those in the vehicle group. The biochemical measurements reflected that these organs had normal functions, as supported by the quantitative data in Tables ​Tables11 and ​and2.2. Moreover, the vehicle group showed no abnormalities or side effects resulting from 10% Tween 20. These findings provided sufficient evidence to conclude that the orally administered extract was safe and did not cause extract-related toxicity.