Angelica keiskei Extract powder

• Product Detail

Product name	Angelica keiskei Extract powder
Latin Name	Angelica keiskei
Active ingredients	Flavones
synonyms	Angelica keiskei, Ashitaba du Japon, Herbe de la Longévité, Japanese Ashitaba, Kenso, Leaves of Tomorrow.
Appearance	Tan fine powder/Light Yellow fine powder
Part used	Herb
Specification	10:1, Flavones 25% UV
Dosage	2000-3000mg daily
Main benefits	Antioxidant, anticancer, anti-inflammatory, antidepressant
Applied industries	Medicine, food additive, dietary supplement

What is Angelica keiskei Extract powder?

According to Wikipedia,Angelica keiskei, commonly known under the Japanese name of Ashitaba (アシタバ or 明日葉 ashitaba, literally "Tomorrow's Leaf"), is a not frost tender perennial plant from the angelica genus with an average growth height of 50–120 cm. It is endemic to Hachijō-jima, though it is artificially cultivated in Izu Ōshima, Mikura-jima, Nii-jima, To-shima and parts of Honshū as well.

The plants additional cultivar epithet koidzumi refers to botanist Gen'ichi Koizumi, while its Japanese nomenclature stems from the above-average regenerative capabilities it exhibits after injury. Harvesting a leaf at the break of day often results in a new sprout growing overnight, being visible the following morning.

Traditionally it is seen as a major contributor to the supposedly healthier, extended lives of the local residents, something that may be based on its substantial levels of vitamin B12 and on the chalconoids that are unique to this species of angelica. At one point in Edo period the haulm's yellow sap was effectively used in the external treatment of smallpox, which prompted Kaibara Ekken to describe the herb in his Yamato honzō (大和本草), under the name of ashitagusa (鹹草), as "a powerful tonic drug." In folk medicine it is claimed to be diuretic, tonic, to improve digestion, and, when applied topically, to speed wound healing and prevent infection. Also its nutritive qualities are said to be the factor behind the internal exiles' and their families' never waning stamina in the face of their arduous compulsory labor.

For similar reasons, it very widely serves as pasture for cows, reckoned to improve the quality of milk as well as the yield and to maintain cattle health at the same time.

>Medicinal Properties

This plant is being studied for nerve growth factor, cancer, menopause, and a sundry of disease conditions.

Chemical constituents of Angelica keiskei Extract powder

>Substantial in vitamin B12 and chalconoids.

>All genus members contain furocoumarins.

>Roots have yielded psoralen, bergapten, xanthotoxin, and angelicin.

>Study isolated seven compounds: 1-cerotol , daucosterol , stigmasterol , quercetin-3-O-β-D-glucopyranside , luteolin-7-rhamno-glucoside , luteolin-7-O-α-D-glucpyranoside and steviol-l3-O-β-glucopyranoside 19-β-glucopyranosyl ester octaacetate.

Benefits of taking Angelica keiskei Extract powder supplements:

> Angelica keiskei Extract powder and antioxidant

Bioavailability of plant pigment phytochemicals in Angelica keiskei in older adults: A pilot absorption kinetic study.

Correa CR1, Chen CY2, Aldini G3, Rasmussen H2, Ronchi CF1, Berchieri-Ronchi C1, Cho SM4, Blumberg JB2, Yeum KJ5.

Abstract

BACKGROUND/OBJECTIVES:

Angelica keiskei is a green leafy vegetable rich in plant pigment phytochemicals such as flavonoids and carotenoids. This study examined bioavailability of flavonoids and carotenoids in Angelica keiskei and the alteration of the antioxidant performance in vivo.

SUBJECTS AND MATERIALS:

Absorption kinetics of phytochemicals in Angelica keiskei were determined in healthy older adults (> 60 y, n = 5) and subjects with metabolic syndrome (n = 5). Subjects consumed 5 g dry Angelica keiskei powder encapsulated in gelatin capsules with a low flavonoid and carotenoid liquid meal. Plasma samples were collected at baseline, 0.5, 1, 2, 3, 4, 5, 6, 7, and 8 h. Samples were analyzed for flavonoids and carotenoids using HPLC systems with electrochemical and UV detection, respectively, and for total antioxidant performance by fluorometry.

RESULTS:

After ingestion of Angelica keiskei increases in plasma quercetin concentrations were observed at 1-3 and 6-8 hr in the healthy group and at all time points in the metabolic syndrome group compared to baseline (P < 0.05). Plasma lutein concentrations were significantly elevated in both the healthy and metabolic syndrome groups at 8 hr (P < 0.05). Significant increases in total antioxidant performance were also observed in both the healthy and the metabolic syndrome groups compared to baseline (P < 0.05).

CONCLUSIONS:

Findings of this study clearly demonstrate the bioavailability of phytonutrients of Angelica keiskei and their ability to increase antioxidant status in humans.

> Angelica keiskei Extract powder and anti-inflammatory

Chalcones from Angelica keiskei attenuate the inflammatory responses by suppressing nuclear translocation of NF-κB.

Chang HR1, Lee HJ, Ryu JH.

Abstract

The ethyl acetate-soluble fraction from the ethanolic extract of Angelica keiskei showed potent inhibitory activity against the production of nitric oxide (NO) in lipopolysaccharide (LPS)-activated RAW 264.7 cells. We identified seven chalcones (1-7) from EtOAc-soluble fractions through the activity-guided separation. Four active principles, identified as 4-hydroxyderrcine (1), xanthoangelol E (2), xanthokeismin A (4), and xanthoangelol B (5), inhibited the production of NO and the expression of proinflammatory cytokines, interleukin (IL)-1β and IL-6, in LPS-activated macrophages. Western blotting and reverse transcription-polymerase chain reaction analysis demonstrated that these chalcones attenuated protein and mRNA levels of inflammatory enzymes such as inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Moreover, these active compounds suppressed the degradation of inhibitory-κBα (I-κBα) and the translocation of nuclear factor κB (NF-κB) into nuclei of LPS-activated macrophages. These data demonstrate that four chalcones (1, 2, 4, and 5) from A. keiskei can suppress the LPS-induced production of NO and the expression of iNOS/COX-2 genes by inhibiting the degradation of I-κBα and nuclear translocation of NF-κB. Taken together, four chalcones from A. keiskei may have efficacy as anti-inflammatory agents.

> Angelica keiskei Extract powder and antidepressant

Xanthoangelol and 4-Hydroxyderricin Are the Major Active Principles of the Inhibitory Activities against Monoamine Oxidases on Angelica keiskei K.

Kim JH1, Son YK, Kim GH, Hwang KH.

Abstract

Monoamine oxidase inhibitors (MAOI) have been widely used as antidepressants. Recently, there has been renewed interest in MAO inhibitors. The activity-guided fractionation of extracts from Angelica keiskei Koidzumi (A. keiskei K.) led to the isolation of two prenylated chalcones, xanthoangelol and 4-hydroxyderricin and a flavonoid, cynaroside. These three isolated compounds are the major active ingredients of A. keiskei K. to inhibit the MAOs and DBH activities. Xanthoangelol is a nonselective MAO inhibitor, and a potent dopamine β-hydroxylase (DBH) inhibitor. IC50 values of xanthoangelol to MAO-A and MAO-B were calculated to be 43.4 μM, and 43.9 μM. These values were very similar to iproniazid, which is a nonselective MAO inhibitor used as a drug against depression. The IC50 values of iproniazid were 37 μM, and 42.5 μM in our parallel examination. Moreover, IC50 value of xanthoangelol to DBH was calculated 0.52 μM. 4-Hydroxyderricin is a potent selective MAO-B inhibitor and also mildly inhibits DBH activity. The IC50 value of 4-hydroxyderricin to MAO-B was calculated to be 3.43 μM and this value was higher than that of deprenyl (0.046 μM) used as a positive control for selective MAO-B inhibitor in our test. Cynaroside is a most potent DBH inhibitor. The IC50 value of cynaroside to DBH was calculated at 0.0410 μM. Results of this study suggest that the two prenylated chalcones, xanthoangelol and 4-hydroxyderricin isolated from A. keiskei K., are expected for potent candidates for development of combined antidepressant drug. A. keiskei K. will be an excellent new bio-functional food material that has the combined antidepressant effect.

> Angelica keiskei Extract powder and adipose tissue& liver.

Ashitaba (Angelica keiskei) extract prevents adiposity in high-fat diet-fed C57BL/6 mice.

Zhang T1, Yamashita Y, Yasuda M, Yamamoto N, Ashida H.

Abstract

Two main chalcones, 4-hydroxyderricin and xanthoangelol, from Ashitaba, which is a food ingredient and a folk medicine in Asia, have been demonstrated to modulate lipid metabolism in 3T3-L1 and HepG2 cells. In this study, we investigated the effects of Ashitaba extract on adiposity in mice fed a high-fat (HF) diet and its underlying mechanisms based on adipose tissue and hepatic lipid metabolism. C57BL/6 mice were fed a normal or HF diet supplemented with Ashitaba extract (0.01% and 0.1%, w/w) for 16 weeks. Ashitaba extract suppressed the HF diet-induced body weight gain and fat deposition in white adipose tissue, reduced plasma cholesterol, glucose, and insulin levels, increased the adiponectin level, lowered triglyceride and the liver cholesterol content, increased phosphorylation of AMP-activated protein kinase (AMPK) in adipose tissue and liver, inhibited lipogenesis in adipose tissue by down-expression of peroxisome proliferator-activated receptor (PPAR) γ, CCAAT/enhancer-binding protein α and sterol regulatory element-binding protein 1 (SREBP1), inhibited lipogenesis in the liver by down-expression of SREBP1 and its target enzyme fatty acid synthase, and promoted fatty acid oxidation by up-expression of carnitine palmitoyltransferase-1A and PPARα. In conclusion, Ashitaba extract can possibly prevent adiposity through modulating lipid metabolism through phosphorylation of AMPK in adipose tissue and liver.

Side effects and safety of Angelica keiskei Extract powder

>Toxicological assessment of Ashitaba Chalcone.

Author information

1Maronpot Consulting LLC, 1612 Medfield Road, Raleigh, NC 27607, United States.

Abstract

The plant Angelica keiskei contains two main physiologically active flavonoid chalcones, 4-hydroxyderricin and xanthoangelol. Known as ashitaba in Japan, powder from the sap is widely consumed for its medicinal properties in Asia as a dietary supplement. Limited previously reported mammalian studies were without evidence of toxicity. GLP studies reported here, including a bacterial reverse mutation assay, a chromosome aberration assay, and an in vivo micronucleus assay are negative for genotoxicity. A GLP- compliant 90-day repeated oral gavage study of ashitaba yellow sap powder containing 8.45% chalcones in Sprague Dawley rats resulted in expected known physiological effects on coagulation parameters and plasma lipids at 300 and 1000 mg/kg/day. Ashitaba-related pathology included a dose-related male rat-specific alpha 2-urinary globulin nephropathy at 100, 300, and 1000 mg/kg/day and jejunal lymphangiectasia in both sexes at 1000 mg/kg/day. All other study parameters and histopathological changes were incidental or not of toxicological concern. Based on these studies ashitaba chalcone powder is not genotoxic with a NOAEL of 300 mg/kg in male and female rats.