Codonopsis pilosula root extract powder

• Product Detail

Product name	Codonopsis pilosula root extract
Latin Name	Codonopsis pilosula (Franch.)
Active ingredients	Tangshenoside, Polysaccharide
synonyms	Pilose Asiabell ,Bastard Ginseng, Bellflower, Bonnet Bellflower, Campanule à Bonnet, Chuan Dang, Codonopsis Modestae, Codonopsis pilosula, Codonopsis Pilosula Modesta, Codonopsis tangshen, Codonopsis tubulosa, Dangshen, Dong Seng, Ginseng Bâtard, Ginseng du Pauvre, Racine de Campanule à Bonnet, Radix Codonopsis, Radix Codonopsis Pilosulae.
Appearance	Brown fine powder
Part used	Root
Specification	Tangshenoside 10%UV, Polysaccharide 30%,50%UV
Dosage	1500-2000mg daily
Main benefits	Antioxidant, anticancer, liver protection, heart disease
Applied industries	Medicine, food additive, dietary supplement, sports nutrition

What is Codonopsis pilosula root extract?

Codonopsis pilosula, also known as dang shen or poor man's ginseng, is a perennial species of flowering plant in the bellflower family. It is native to Asia, where it grows in forests, meadows, and scrub.

Codonopsis pilosula (Dang Shen) Important Chinese medicinal herb similar in action to ginseng. Sweet tasting roots have been shown to boost red cell and hemoglobin counts in rabbits.

Used as a tonic (in humans) in anemia, fatigue, shallow and strained breathing, poor appetite, dyspepsia, and diabetes.

Chemical constituents of Codonopsis pilosula root extract

Codonopsis pilosula containing sterols:α-　Spinasterol,Stigmasterol,α-Spinasterol-β-D-glucoside,Stigmasterol-β-D-glucoside etc.

saccharides and glycosides: Inulin,Fructose,n-Hexyl-β-D-glucopyranoside,Ethyl-α-D-fructofurano- side.

Alkaloids and nitrogen composition: Choline,n-Butyl-allophanate,Codopiloic acid,5- Hydroxy-2-pyridinemethanol,Nicotine etc.

volatile components: Caproic acid,Enanthic acid,Caprylic acid,Pelargonic acid,Lauric acid,Azelaic acid,Myristic acid,Pentadecanoic acid,Palmitic acid,Margaric acid,Octadecadienoic acid,2,4-Nonadienic acid,n-Pentadecane,α-Curcumene,n-Heptadecane,n-Octadecane,n-Nonadecane,n-Heneicosane,n-Docosane,Methyl myristate,Methyl pentadecanoate,Methyl palmitate,Methyl stearate,Methyl octadecadienoate,Pinene,Ethyl palmitate,Methyl caprylate etc.

Triterpene and other ingredients: Taraxer- ol,Taraxeryl acetate,Friedelin,Atractylnolide,Syringaldehyde,Vanillic acid,2-Furancarboxylate,Codonolactone,5-Hydroxy- methyl furaldehyde,5-Methoxyl- furaldehyde etc.

Benefits of taking Codonopsis pilosula root extract supplements:

Codonopsis pilosula and heart disease

>Dung-shen (Codonopsis pilosula) attenuated the cardiac-impaired insulin-like growth factor II receptor pathway on myocardial cells.

(Source-Department of Emergency, China Medical University Beigang Hospital, Yunlin County, Taiwan.)

Abstract

Previous studies from our lab showed that increase in AngII in H9c2 cells causes elevated IGFII and IGFIIR through MEK and JNK, leading to rise in intracellular calcium, calcineurin activation by PLC-β3 via Gαq, insertion into mitochondrial membranes of Bad, and apoptosis via caspases 9 and 3. Codonopsis pilosula is traditionally used to lower blood pressure. The purpose of our study is to investigate if C. pilosula attenuates AngII plus Leu(27)-IGFII-induced calcium influx and apoptosis in H9c2 cardiomyoblasts. C. pilosula significantly attenuated AngII induced IGFIIR promoter activity. Leu(27)-IGFII was applied to enhance the AngII effect. C. pilosula also reversed Ca(2+) influx, MOMP and apoptosis increased by AngII plus Leu(27)-IGFII. Molecular markers in IGFIIR apoptotic pathway (IGFIIR, calcineurin, etc.) and IGFIIR-Gαq association were downregulated by C. pilosula. However, p-Bad(Ser136) and Bcl-2 were increased. Therefore, C. pilosula suppresses AngII plus Leu(27)-IGFII-induced IGFII/IGFIIR pathway in myocardial cells.

Codonopsis pilosula and gastric cancer

Chinese medicine formula "Weikang Keli" induces autophagic cell death on human gastric cancer cell line SGC-7901.

(Source-Department of Oncology, Jiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing 210028, Jiangsu, China.)

Abstract

Weikang Keli (constitutes of Root of Codonopsis pilosula, Rhizoma Atractylodis Macrocephalae, Rhizoma Curcumae Aeruginosae, Rhizoma Pinelliae, Actinidia chinensis Planch, and Rhodiola rosea) is a well known Chinese herbal formula for gastric cancer therapy in clinical treatment. However, the detailed molecular mechanisms involved are still not fully understood. In this study, we found that Weikang Keli could induce patterns of autophagy in SGC-7901 cells, including intracellular vacuole formation, microtubule-associated protein 1 light chain 3 (LC3) conversion. Hoechst 33258 staining and Western blot analysis of apoptosis-related proteins showed that WK induced SGC-7901 cell death was not through apoptosis. In vivo study also revealed that i.g. administration of Weikang Keli once a day for 25 days could significantly reduce tumor volumes by about 50%. Collectively, the current data indicated that Weikang Keli induced gastric cancer cell death by autophagy effects.

Codonopsis pilosula and renoprotective effect

Protective effect of a polysaccharide from stem of Codonopsis pilosula against renal ischemia/reperfusion injury in rats.

(Source-Nephrology Division, Tangdu Hospital, The Fourth Military Medical University, Xi'an 710038, China.)

Abstract

In this study, we purified a homogeneous polysaccharide (S-CPPA1) with a molecular weight (Mw) of 133.2 kDa from the stem of Codonopsis pilosula for the first time. Gas chromatography (GC) analysis identified that S-CPPA1 contained glucose, galactose, and arabinose with a molar ratio of 10.5:3.4:1.7, along with a trace of mannose. Methylation analysis suggested S-CPPA1 was a branched polysaccharide, with five glucosidic linkage forms, namely (1→4)-linked Glcp (residue A), (1→6)-linked Galp (residue B), (1→2,6)-linked Glcp (residue C), (1→5)-linked Araf (residue D), and non-reducing terminal (1→)-linked Glcp (residue E). The protective effect of S-CPPA1 on kidney ischemia/reperfusion (I/R) injury was also evaluated. Blood urea nitrogen (BUN), creatinine and TNF-α levels, as well as lactate dehydrogenase (LDH) and alanine transaminase (AST) activities were elevated in the I/R group as compared to the sham group. On the other hand, S-CPPA1 treatment reversed all these biochemical indices, as well as histopathological alterations, which were induced by I/R. The findings imply that S-CPPA1 plays a causal role in the protection against I/R-induced renal injury and its renoprotective effect is probably mediated by inhibiting the proinflammatory cytokine TNF-α release.

Codonopsis pilosula and tumor

The inhibitory effect of a polysaccharide from Codonopsis pilosula on tumor growth and metastasis in vitro.

(Source-Department of Medical Oncology, The Second Affiliated Hospital, Harbin Medical University, Harbin 150081, China.)

Abstract

In this study, we prepared an acidic polysaccharide (CPPA) from the roots of Codonopsis pilosula. The effects of CPPA on tumor cell growth, invasion, and migration were examined in vitro. The CPPA not only induced a potent inhibitory effect on the invasion and migration potential of human epithelial ovarian cancer HO-8910 cells in vitro, evaluated by wound healing, transwell and cell adhesion assays, but also had an efficient anti-proliferation effect on tumor cells. Moreover, the CD44 expression on the HO-8910 cells was also attenuated by CPPA treatment. Therefore, our results indicate that CPPA may be a potential candidate compound for the prevention of tumor metastasis, presumably by inhibiting invasion, migration and adhesion of tumor cells, as well as the CD44 expression on the tumor cells.

>The contribution of side chains to antitumor activity of a polysaccharide from Codonopsis pilosula.

(Source-School of Pharmaceutical Sciences, Jilin University, Changchun 130021, China.)

Abstract

In order to assess the potential contribution of the side chains of a polysaccharide (CPPW1) from the roots of Codonopsis pilosula to the biological activities, we chose CPPW1 and its backbone (CPPW1B) as the research targets to compare them with their antitumor and immunomodulatory activity. The results demonstrated CPPW1 could significantly inhibit the tumor growth of H22-bearing mice and simulate lymphocyte proliferation. Meanwhile the phagocytic capability of macrophages and NO production were also enhanced. However, CPPW1B could only inhibit the tumor weight and did not work to immune system at all. Additionally, both CPPW1 and CPPW1B had no toxicity in vivo. Taken together with all data, we found the sugar side chains attached to the backbone of CPPW1 played a pivotal role in fighting against tumor and activating immune system.

Codonopsis pilosula and immunity activity

Structural characterization of a water-soluble polysaccharide from the roots of Codonopsis pilosula and its immunity activity.

(Source-Department of Pharmacology, Qiqihar Medical University, Qiqihar 161042, PR China.)

Abstract

The water-soluble polysaccharide (CPP), with a molecular mass of 1.1x10(4) Da, was obtained from the roots of Codonopsis pilosula. Structure feature investigation by a combination of chemical and instrumental analysis revealed that CPP had a backbone consisting of (1-->3)-linked-beta-D-galactopyranosyl, (1-->2, 3)-linked-beta-D-galactopyranosyl and (1-->3)-linked-alpha-D-rhamnopyranosyl residues, which were branched with two glycosyl residues composed of alpha-L-arabinose-(1-->5)-alpha-L-arabinose(1-->linked residues at the O-2 position of galactosyl along the main chain in the ratio of 1:1:2:1:1. Preliminary immunological tests in vitro showed CPP could stimulate concanavalin A (ConA)- or lipopolysaccharide (LPS)-induced lymphocyte proliferation in a dose-dependent manner.

 Side effects and safety of Codonopsis pilosula root extract

Codonopsis pilosula for thousands of years in China, it is safe, is also no reports of side effects.