What is Chasteberry?
Chasteberry
is a small brown berry fruit of the chaste tree which is about the size of
peppercorns and smells like peppermint.Chasteberry is an herb used for the
treatment of menstrual problems. Women have used chasteberry for thousands of
years to help reduce the symptoms menstrual problems and to stimulate the
production of breast milk. During the middle ages, monks reportedly used chasteberry
to decrease sexual desire and preserve chastity. Today, chasteberry is used to
reduce the symptoms of PMS and menopause, to ease breast pain, for some types
of infertility, and acne.
Chemical constituents of Chasteberry Extract:
Chasteberry contains
iridoids, flavonoids, diterpenoids, progestins, essential oils, and
ketosteroids. glycosides have been isolated from the leaves and fruit of
the plant .Flavonoid content has been identified in chaste tree leaves,
flowers, and fruits. Flavonoids were isolated from the root bark.
The
alkaloid vitricine is present in the plant. Vitexlactam A, a labdane diterpene,
has been isolated from the fruit of Chasteberry
Benefits of
taking Chasteberry Extract
powder supplements:
1.Chasteberry
is believed to work by suppressing the release of prolactin from the pituitary
gland. 1-4 Prolactin
is a hormone that naturally rises during pregnancy to stimulate milk production.
>Casticin, a flavonoid
isolated from Chasteberry, inhibits prolactin release in vivo and in vitro.
YE Q1, ZHANG QY, ZHENG CJ, WANG
Y, QIN LP.
Abstract
AIM:to investigate the
anti-hyperprolactinemia activity of casticin, a flavonoid isolated from Chasteberry,
and elucidate its molecular mechanism.
METHODS:
hyperprolactinemia (MIHP) was
induced by administration of metoclopramide dihydrochloride (50 mg/kg, tid, ip,
for 10 d) in SD rats and the primary pituitary cells were prepared from the
pituitary glands of the SD rats. Prolactin concentrations were measured using a
radioimmunoassay. Cell viability was measured using an MTT assay. The mRNA
expression of estrogen receptor alpha and beta in rat pituitary cells was
measured using semi-quantitative RT-PCR analysis.
CONCLUSION:
casticin inhibited the release
of prolactin from pituitary cells of SD rats stimulated with E2 in vivo and in
vitro. These effects might be related with inhibiting the ERα mRNA expression
and increasing the ERβ mRNA expression.
2. Chasteberry
extract in the manufacturing of a medication for Mastalgia - sore breasts or
breast tenderness associated with PMS (Pre-Menstrual Syndrome) and menopause.
> Herbal
medicine for the management of polycystic ovary syndrome (PCOS) and associated
oligo/amenorrhoea and hyperandrogenism; a review of the laboratory evidence for
effects with corroborative clinical findings.
Arentz S, Abbott JA, Smith CA,
Bensoussan A.
Abstract
BACKGROUND:
Polycystic ovary syndrome
(PCOS) is a prevalent, complex endocrine disorder characterised by polycystic
ovaries, chronic anovulation and hyperandrogenism leading to symptoms of
irregular menstrual cycles, hirsutism, acne and infertility. Evidence based
medical management emphasises a multidisciplinary approach for PCOS, as
conventional pharmaceutical treatment addresses single symptoms, may be
contra-indicated, is often associated with side effects and not effective in
some cases. In addition women with PCOS have expressed a strong desire for
alternative treatments. This review examines the reproductive endocrine effects
in PCOS for an alternative treatment, herbal medicine. The aim of this review
was to identify consistent evidence from both pre-clinical and clinical
research, to add to the evidence base for herbal medicine in PCOS (and
associated oligo/amenorrhoea and hyperandrogenism) and to inform herbal
selection in the provision clinical care for these common conditions.
METHODS:
We undertook two searches of
the scientific literature. The first search sought pre-clinical studies which
explained the reproductive endocrine effects of whole herbal extracts in
oligo/amenorrhoea, hyperandrogenism and PCOS. Herbal medicines from the first
search informed key words for the second search. The second search sought
clinical studies, which corroborated laboratory findings. Subjects included
women with PCOS, menstrual irregularities and hyperandrogenism.
CONCLUSIONS:
Preclinical and clinical studies
provide evidence that six herbal medicines may have beneficial effects for
women with oligo/amenorrhea, hyperandrogenism and PCOS. However the quantity of
pre-clinical data was limited, and the quality of clinical evidence was
variable. Further pre-clinical studies are needed to explain the effects of
herbal medicines not included in this review with current clinical evidence but
an absence of pre-clinical data.
3.take a Chasteberry capsule daily can help infertility ,by
natural increase in progesterone levels.
> Double-blind,
placebo-controlled study of Fertilityblend: a nutritional supplement for
improving fertility in women.
Westphal LM1, Polan ML, Trant
AS.
Author information
Department of
Gynecology/Obstetrics, Stanford University School of Medicine, Stanford, CA
94305, USA.
Abstract
PURPOSE:
To determine the impact of
nutritional supplementation on female fertility.
METHODS:
A double blind,
placebo-controlled study of the effects of FertilityBlend for Women, a
proprietary nutritional supplement containing chasteberry, green tea,
L-arginine, vitamins (including folate), menstrual cycle length, pregnancy rate
and side-effects.
CONCLUSION:
Nutritional supplements could
provide an alternative or adjunct to conventional fertility therapies
Side effects and safety of Chasteberry Extract powder:
Special Precautions & Warnings:
>Pregnancy
and breast-feeding: Using Chasteberry Extract during pregnancy or
breast-feeding is POSSIBLY UNSAFE. The concern is that Chasteberry Extract, can
interfere with hormones. Don’t use Chasteberry Extract if you are pregnant or
breast-feeding.