Hemp seed Extract

• Product Detail

Product name	hemp seed Extract
Latin Name	Cannabis sativa L.
Active ingredients	Protein
synonyms	Ma Ren, Huo Ma Ren, Cannabis sativa extract
Appearance	Brown fine powder
Part used	Seed
Specification	protein 42% HPLC/20:1TLC
Dosage
Main benefits	Constipation, weight loss, incrasing immunnity
Applied industries	Medicine, food additive, dietary supplement, sports nutrition

What is hemp seed Extract?

Ma Ren or Huo Ma Ren is also known as hemp seed. The sweet and neutral herb has been used in TCM to treat constipation, acute infection of urinary tract, rheumatoid arthritis, diarrhea, irregular menses, etc., as it moistens the Intestines, promotes bowel movement, etc., by enhancing the functions of spleen, stomach, large intestine channels.

Hemp seeds are produced from the hemp plant, Cannabis sativa L. While hemp is commonly confused with marijuana, as it belongs to the same family, the two plants are quite different. Most notably is the level of THC, or delta-9-tetrahydrocannabinol. Hemp contains less than 1% of the psychoactive drug while marijuana contains up to 20% or more.

Hemp seed food products are also considered more allergy-free than many other seeds. Hemp seeds contain the perfect balance of essential amino acids for sustaining good health. In addition, hemp seed oil contains necessary fatty acids, also known as good fats. Not only can hemp seeds provide valuable nutritional benefits to people, but they can also be used in pet foods and taste good too.

Chemical constituents of hemp seed Extract

Hemp seeds are rich in essential fatty acids. The oil in the seeds is a source of the omega-3 fatty acid alpha-linolenic acid, ALA, as well as omega-6 fatty acid gamma-linolenic acid, or GLA.

Benefits of taking hemp seed Extract supplements:

Constipation

>Efficacy of a Chinese herbal proprietary medicine (Hemp Seed Pill) for functional constipation.

(School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China.)

Abstract

OBJECTIVES:

Functional constipation (FC) is a common clinical complaint. Despite a lack of consolidated evidence, Chinese herbal medicine (CHM) has become a popular alternative treatment for this condition. The aim of this study was to assess, with a rigidly designed study, the efficacy and safety of a CHM proprietary medicine, Hemp Seed Pill (HSP), in optimal dosage for treating FC.

METHODS:

This study comprised two parts: trial I, a dose determination study, and trial II, a placebo-controlled clinical study. In trial I, the optimal dosage of HSP was first determined from among three doses (2.5, 5.0, and 7.5 g b.i.d.). In trial II, a randomized double-blind study, the efficacy and safety of HSP for FC patients (Rome III criteria) in excessive syndrome as defined by traditional Chinese medicine (TCM) theory were compared with placebo. All participants in trials underwent a 2-week run-in, an 8-week treatment, and an 8-week follow-up. The primary end point was the responder rate for complete spontaneous bowel movement (CSBM) during treatment. Participants with a mean increase of CSBM ≧ 1/week compared with their baselines were defined as responders. Secondary outcome measures included responder rate during follow-up, individual and global symptom assessments, and reported adverse effects (AEs).

RESULTS:

The dose of 7.5 g b.i.d. showed better therapeutic effect than that of 2.5 and 5.0 g b.i.d. among 96 subjects (32 per arm) in trial I and was therefore selected for comparison with placebo in trial II. In trial II, 120 subjects were randomized into two arms (60 per arm). Responder rates for the HSP and placebo groups were 43.3 and 8.3% during treatment and 30.0 and 15.0% in the follow-up period, respectively (P<0.05). Those in the HSP group showed benefit in terms of increased CSBM, relief in the severity of constipation and straining of evacuation, and effective reduction in the use of rescue therapy when compared with placebo. No serious AE was reported.

CONCLUSIONS:

HSP (7.5 g b.i.d.) is safe and effective for alleviating FC for subjects in excessive syndrome. Optimal dose determination may be crucial for all CHM studies.

Immunomodulatory

Immunomodulatory and therapeutic effects of Hot-nature diet and co-supplemented hemp seed, evening primrose oils intervention in multiple sclerosis patients.

(Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; School of Nutrition and Health, Tabriz University of Medical Sciences, Tabriz, Iran.)

Abstract

BACKGROUND:

Multiple sclerosis (MS) is the most chronic and inflammatory disorder. Because of limited efficacy and adverse side effects, identifying novel therapeutic and protective agents is important. This study was aimed to assess the potential therapeutic effects of hemp seed and evening primrose oils as well as Hot-nature dietary intervention on RRMS patients.

METHODS AND MATERIALS:

In this double blind, randomized trial, 100 MS patients with EDSS<6 were allocated into 3 groups: "Group A" who received co-supplemented hemp seed and evening primrose oils with advised Hot-nature diet, "Group B" who received olive oil, "Group C" who received the co-supplemented oils. Mizadj, clinically EDSS and relapse rate as well as immunological factors (IL-4, IFN-γ and IL-17) were assessed at baseline and after 6 months.

RESULTS:

Mean follow-up was 180±2.9 SD days (N=65, 23 M and 42 F aged 34.25±8.07 years with disease duration 6.80±4.33 years). There was no significant difference in studies parameters at baseline. After 6 months, significant improvements in Mizadj, EDSS and relapse rate were found in the groups A and C, while the group B showed a border significant decrease in relapse rate. Immunological parameters showed improvement in groups A and C, whereas there was worsening condition for group B after the intervention.

CONCLUSION:

The co-supplemented hemp seed and evening primrose oils with Hot-nature diet have beneficial effects in improving of clinical score in RRMS patients which were confirmed by immunological findings.

Antioxidant

>Reverse-phase HPLC separation of hemp seed (Cannabis sativa L.) protein hydrolysate produced peptide fractions with enhanced antioxidant capacity.

(Department of Human Nutritional Sciences and the Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba, Winnipeg, MB, R3T 2N2, Canada.)

Abstract

Hemp seed protein hydrolysate (HPH) was produced through simulated gastrointestinal tract (GIT) digestion of hemp seed protein isolate followed by partial purification and separation into eight peptide fractions by reverse-phase (RP)-HPLC. The peptide fractions exhibited higher oxygen radical absorbance capacity as well as scavenging of 2,2-diphenyl-1-picrylhydrazyl, superoxide and hydroxyl radicals when compared to HPH. Radical scavenging activities of the fractionated peptides increased as content of hydrophobic amino acids or elution time was increased, with the exception of hydroxyl radical scavenging that showed decreased trend. Glutathione (GSH), HPH and the RP-HPLC peptide fractions possessed low ferric ion reducing ability but all had strong (>60 %) metal chelating activities. Inhibition of linoleic acid oxidation by some of the HPH peptide fractions was higher at 1 mg/ml when compared to that observed at 0.1 mg/ml peptide concentration. Peptide separation resulted in higher concentration of some hydrophobic amino acids (especially proline, leucine and isoleucine) in the fractions (mainly F5 and F8) when compared to HPH. The elution time-dependent increased concentrations of the hydrophobic amino acids coupled with decreased levels of positively charged amino acids may have been responsible for the significantly higher (p < 0.05) antioxidant properties observed for some of the peptide fractions when compared to the unfractionated HPH. In conclusion, the antioxidant activity of HPH after simulated GIT digestion is mainly influenced by the amino acid composition of some of its peptides.

Other Applications

>Antidepressant-like effect

> Atherogenesis and contractile function

>Complications of menopause

> Functional constipation

>Anti-neoplastic chemotherapy, nausea, vomitting and analgesic effects

> Immunomodulation effect and anti fatigue

> Hypercholesterolemia

Side effects and safety of hemp seed Extract

1. Overdoses and prolonged period of use can damage circulation and cause impotence

2. Do not use the herb in newborn, children or if you are pregnant or breast feeding without consulting first with the related field specialist

3. Overdoses can also cause caused nausea, vomiting, diarrhea, numbness in the limbs, antsy and anxiety, confusion.

Dosage of hemp seed Extract supplement:

Anyone taking anticoagulant drugs, since hemp seeds inhibit platelets and may pose a bleeding risk.

Consult your physician if you have any questions about the proper use of hemp seed Extract supplements.