Jujube seed Extract

• Product Detail

Product name	Jujube seed Extract
Latin Name	Zizyphus jujuba Mill
Active ingredients	Jujubosides
synonyms	Anèbe, Azufaifo, Badar, Ber, Black Date, Black Jujube, Chinese Date, Chinese Jujube, Da Zao, Date Seed, Datte Chinoise, Datte Noire, Fructus Jujubae, Fructus Ju Jubae, Hei Zao, Hong Zao, Jujube Chinois, Jujube Plum, Jujube Noir, Jujube Rouge, Jujubi, Jujubier, Red Date, Red Jujube Date, Rhamnus zizyphus, Semen Ziziphi Spinosae, Sour Chinese Date, Sour Date, Suan Zao Ren, Zao, Zefzouf, Ziziphi Spinosae, Ziziphus jujuba, synonyms Ziziphus sativa, Ziziphus spinosa, Ziziphus vulgaris, Ziziphus zizyphus, Zizyphi Fructus, Zizyphus, Zizyphus jujuba, Zyzyphus jujube.
Appearance	Red Brown fine powder
Part used	Seed & Fruit
Specification	Jujuboside 80% UV/Polysaccharides 15%,30% UV/Polyphenols 10%,30% UV
Dosage	1500-2000mg daily
Main benefits	Insomnia, Anti-inflammation, Cardiovascular disease
Applied industries	Medicine, food additive, dietary supplement, sports nutrition

What is Jujube Seed Extract?

According to wikipedia,The fruits and seeds are used in Chinese and Korean traditional medicine, where they are believed to alleviate stress, and traditionally for antifungal, antibacterial, antiulcer, anti-inflammatory, sedative, antispastic, antifertility/contraception, hypotensive and antinephritic, cardiotonic, antioxidant, immunostimulant, and wound healing properties.The jujube-based Australian drink 1-bil avoids making specific stress-related claims, but does suggest drinking 1-bil "when you feel yourself becoming distressed".

The fruit and seed also contains flavonoids, sugars, fiber, calcium, phosphorus, iron and Vitamins A, B2 and C.

The sedative properties are reported to come from the saponin components. Saponins are also known to reduce cholesterol levels, have anti-tumor capability by inhibiting tumor growth and in some cases initiate programmed cell death (apoptosis), boost the immune system and fight off infections, elevate mood (anti-anxiety) and prevent cell damage by acting as an antioxidant.The saponin components have triterpene structure and are generally known as jujubosides A and B and are responsible for this fruits ability to have a calming effect.  These jujubosides do much further than act as a mood enhancer by reducing hyperactivity and reducing hypertension.  This makes jujubosides useful in treating sleep disorders, anxiety and cardiovascular problems.

Chemical constituents of Jujube Seed Extract

At present the main Jujubosides extracted from Jujube Seed.also contains betulin, betulinic acid, ceanothic acid, coumarin, jujubosides, oleanic acid, sapponins and ursolic acid.

Benefits of taking Jujube Seed Extract supplements:

Insomnia

>Hypnotic effect of jujubosides from Semen Ziziphi Spinosae.

(Source-Department of Pharmacology, Peking University, School of Basic Medical Science, 38 Xueyuan Lu, Beijing 100191, China.)

Abstract

ETHNOPHARMACOLOGICAL SIGNIFICANCE:

Semen Ziziphi Spinosae, the seed of Ziziphus jujuba Mill. var. spinosa (bunge) Hu ex H.F. Chow has been widely used in treating insomnia and anxiety.

AIM OF THE STUDY:

In this study, we investigated the hypnotic effect of jujubosides, one of the major components (saponin) of Semen Ziziphi Spinosae, in both day and night period.

MATERIALS AND METHODS:

After the administration of jujubosides (9 mg/kg once per day for 3 days), sleep parameters were examined by EEG and EMG analysis in normal rats and the action of jujubosides on pentobarbital-induced sleep assessed by the loss-of righting reflex.

RESULTS:

During daytime (9:00-15:00), jujubosides significantly increased the total sleep and rapid eye movement (REM) sleep without significant influence on non-REM (NREM) sleep. During nighttime (21:00-3:00), jujubosides significantly increased the total sleep and NREM sleep especially the light sleep while showed no significant effect on REM sleep and slow wave sleep (SWS). In pentobarbital-treated mice, jujubosides significantly augmented the hypnotic effect of pentobarbital (45 mg/kg, i.p.), proved by increasing sleep time and this augmentative effect was potentiated by 5-hydroxytryptophan (2mg/kg, i.p.). Furthermore, jujubosides inhibited the para-chlorophenylalanine-induced suppression of pentobarbital-induced hypnosis.

CONCLUSIONS:

These results suggested that the hypnotic effect of jujubosides on normal rats may be influenced by circadian rhythm and the serotonergic system may involve in the hypnotic effect of jujubosides. Jujubosides may be good source of lead compounds for novel hypnotics.

Anti-inflammation

>Possible attenuation of nitric oxide expression in anti-inflammatory effect of Ziziphus jujuba in rat.

(Source-Department of Pharmacology, I.S.F. College of Pharmacy, Moga, 142001, Punjab, India. )

Abstract

The hydroalcoholic extract of fruits of Ziziphus jujuba (ZJ) was investigated for its anti-inflammatory effect using acute and chronic models of inflammation in rat. Wistar albino rats of either sex were employed in the present study (n = 6). Acute inflammation was induced by subplantar administration of carrageenan (1%) in rat hind paw. Chronic inflammation was induced by interscapular implantation of a sterile cotton pellet (50 mg). ZJ extract as test drug and indomethacin (10 mg/kg) as standard were used. Serum nitrite/nitrate was also estimated to determine the expression of nitric oxide. In the acute study, carrageenan (1%) administration caused marked paw edema. Pretreatment with ZJ extract exhibited marked dose-dependent attenuation in edema compared to control. In the chronic study, interscapular implantation of sterile cotton pellets caused significant granuloma formation after 7 days, serving as control. ZJ extract significantly decreased granuloma tissue formation compared to control. The serum nitrite/nitrate level was significantly increased after 7 days in the control group due to chronic inflammation, but was decreased by ZJ extract. Moreover, phytochemical studies indicated the presence of jujubosides, flavonoids and terpenes, which may produce the marked anti-inflammatory effect of ZJ fruit in acute and chronic inflammation, possibly by inhibiting nitric oxide expression. The study provides a scientific and ethnopharmacological rationale for the therapeutic use of ZJ fruit as an anti-inflammatory agent.

Other use

> hypotensive effect

> anti-myocardial ischemia.

> regulate blood fat

> Antiarrhythmic

> Improve the cellular immune ability

Side effects and safety of Jujube Seed Extract

Pregnancy and breast-feeding: Not enough is known about the use of jujube during pregnancy and breast-feeding. Stay on the safe side and avoid use.