Dendrobium Nobile Powder Extract

• Product Detail

Product name	Dendrobium Nobile Powder Extract
Latin Name	Dendrobium nobile
Active ingredients	alkaloids
synonyms	Dendrobe Noble, Dendrobium Extract, Dendrobium nobile, Dendrobium officinale, Extrait de Dendrobium, Jin Chai Shi Hu (D. nobile), Nobile Dendrobium (D. nobile), Orchid Stem, Stem-Orchid, Tie Pi Shi (D. officinale), Vinterdendrobium (D. nobile).
Appearance	Brown fine powder
Part used	Stem
Specification	5:1 10:1 20:1
Dosage	1500-2000mg daily
Main benefits	Antioxidant, anticancer, liver protection, Neuroprotective
Applied industries	Medicine, food additive, dietary supplement, sports nutrition

What is Dendrobium Nobile Powder Extract?

The Noble Dendrobium, Dendrobium nobile, is a member of the family Orchidaceae. It has become a popular cultivated decorative house plant, because it produces colourful blooms in winter and spring, at at time when little else is in flower. It is also one of the 50 fundamental herbs used in traditional Chinese medicine, know as shí hú (Chinese: 石斛) or shí hú lán (Chinese: 石斛兰).

Dendrobium is in the orchid plant family. This type of orchid is native to China, Hong Kong, Taiwan, India, Thailand, Vietnam, and other temperate and tropical Asian regions.

This species was first known from China and was later imported for cultivation into Europe from India. Many horticultural varieties of this species were named in the 19th century. The specific epithet 'nobile' means noble, and the common name 'noble dendrobium' is sometimes used, although hardly needed as the Latin name is so well known.

According to traditional Chinese medicine,It is used to nourish and stimulate the stomach. A tea made from the stems of this and other Dendrobium species is taken for complaints such as fever, sunstroke and excessive perspiration.

Chemical constituents of Dendrobium Nobile Powder Extract

Dendrobium Nobile Powder Extract contains alkaloids 0.3%, dendrobine, nobilonine, dendramine, dendroxine, 6-hydroxydendroxine, 4-hydroxydendroxine, nobilmethylene etc.

Benefits of taking Dendrobium Nobile Powder Extract

supplements:

Dendrobium Nobile Powder Extract and hepatic fibrosis

>Selective apoptosis in hepatic stellate cells mediates the anti fibrotic effect of phenanthrenes from Dendrobium nobile.

(Source-College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Korea.)

Abstract

Regardless of the etiology, cellular death of the liver parenchymal hepatocyte seems to be a primary event of hepatic fibrogenesis, which ultimately results in hepatic stellate cell (HSC) activation and the synthesis of extracellular matrix proteins. Recently it has been demonstrated that hepatic fibrosis can be a reversible process when the stimulus is properly eliminated. Apoptotic removal of active HSC is considered an essential part of the resolution. By employing the HSC cell line, HSC-T6, it was found that the methanol extract of Dendrobium nobile stem significantly inhibited the proliferation of HSC-T6 cells. Three phenanthrenes, denbinobin, fimbriol B and 2,3,5-trihydroxy-4,9-dimethoxyphenanthrene isolated from D. nobile were proven to inhibit HSC proliferation. Growth arrest of HSCs by these compounds was accompanied by cellular loss via autophagy-linked apoptosis. The maximal dose of these compounds, however, had little effect on primary cultured hepatocytes in rats. Collagen deposition in HSC-T6 cells was attenuated by these phenanthrenes. Collectively, the above results demonstrated that denbinobin, fimbriol B and 2,3,5-trihydroxy-4,9-dimethoxyphenanthrene exhibited antifibrotic activities possibly by the induction of selective cell death in HSCs but not in hepatocytes, implying that these compounds may be useful candidates for developing therapeutic agents for the prevention and treatment of hepatic fibrosis.

Dendrobium Nobile Powder Extract and cancer

Denbinobin, a phenanthrene from dendrobium nobile, inhibits invasion and induces apoptosis in SNU-484 human gastric cancer cells.

(Source-College of Pharmacy, Duksung Women's University, 419 Ssangmun-Dong, Seoul 132-714, Republic of Korea.)

Abstract

Dendrobium nobile is widely used as an analgesic, an antipyretic, and a tonic to nourish the stomach in traditional medicine. Mounting evidence suggests an antitumor activity of denbinobin, a major phenanthrene isolated from stems of Dendrobium nobile. The present study aimed to investigate the inhibitory effect of denbinobin on the invasive ability of human cancer cells. The cytotoxicity of denbonobin was examined in several human cancer cell lines including SK-Hep-1 hepato-carcinoma cells, SNU-484 gastric cancer cells, and HeLa cervix cancer cells. Because SNU-484 cells showed the lowest IC50 value, we examined the effect of denbinobin on the invasive ability of SNU-484 cells. The present study revealed, for the first time, that denbinobin inhibits the invasive phenotype of SNU-484 human gastric cancer cells in a dose-dependent manner. Expressions of matrix metalloproteinase (MMP)-2 and MMP-9 were significantly decreased by denbinobin, suggesting that MMP-2/-9 may be responsible for the anti-invasive activity of denbinobin. We also provide evidence that denbinobin induces apoptosis through down-regulation of Bcl-2 and an up-regulation of Bax. Taken together, this study demonstrates that denbinobin inhibits invasion and induces apoptosis in highly invasive SNU-484 human gastric cancer cells. Given that gastric cancer has been estimated to be one of the most common causes of cancer-related death among Asians and the major cause of death from gastric cancer is the metastatic spread of the disease, our findings may provide useful information regarding the application of denbinobin as a chemopreventive agent that could prevent or alleviate metastatic gastric cancer.

Dendrobium Nobile Powder Extract and Neuroprotective effect

Neuroprotective effects of SG-168 against oxidative stress-induced apoptosis in PC12 cells.

(Source-Department of Food Science and Biotechnology, Kyungnam University, Masan, Republic of Korea.)

Abstract

Postmortem examinations of tissues of humans and rodents with a host of neurodegenerative conditions, including Alzheimer's and Parkinson's diseases, have identified oxidative damage in proteins, lipids, and DNA. The aim of this study was to better understand the cellular mechanisms of neuronal cell degeneration induced via oxidative stress and the protective roles of bioactive substance. In order to achieve this aim, we established a screening program to discover therapeutic agents that exhibit preferential neuroprotective activity in H(2)O(2)-treated PC12 cells. During the course of our screening program, we isolated an active compound, SG-168, from Dendrobium nobile Lindley and identified it as a neuroprotective agent. SG-168 was identified as a compound with an acetal skeleton, a prototypical compound, by electrospray ionization-mass spectrometry analysis and various nuclear magnetic resonance spectroscopic methods. The protective effect of SG-168 in PC12 cells with H(2)O(2)-induced oxidative damage was investigated by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide reduction assay. As expected, incubation with H(2)O(2) for 2 hours resulted in cell viability of 31.8% compared to the control, while pretreatment of SG-168 increased cell viability by 15-50% compared to the H(2)O(2)-stressed control cells. These results showed that SG-168 inhibits H(2)O(2)-induced apoptotic cell death. Interestingly, flow cytometric analysis showed that H(2)O(2)-treated PC12 cells incubated with SG-168 exhibited greatly suppressed apoptosis. In summation, the results of this study suggest that SG-168 has potential as a new antioxidant agent against neuronal diseases.

>Inhibitory effects of Dendrobium alkaloids on memory impairment induced by lipopolysaccharide in rats.

(Source-Department of Pharmacology, Zunyi Medical College, Zunyi, PR China.)

Abstract

Dendrobium alkaloids (DNLA), extracted from Dendrobium nobile Lindl. whose botanical name is Dendrobium moniliforme, Orchidaceae family, were studied for their effect on lipopolysaccharide (LPS)-induced memory impairment in rats. SD rats were pretreated with DNLA (40, 80, 160 mg/kg/d for 7 d), followed by LPS (50 µg) injection into the right lateral ventricle to produce memory impairment. DNLA treatment continued for another 13 days. The spatial behavior was tested by the Morris water maze; the level of tumor necrosis factor receptor 1 (TNFR1) mRNA was detected by real time RT-PCR, and the protein level of TNFR1, nuclear factor kappa-B (NF- κB) and phosphorylated p38 mitogen-activated protein kinases (p-p38 MAPK) by Western blotting. The results showed that DNLA significantly improved the neurobehavioral performance and prevented LPS-induced elevation in TNFR1 mRNA and protein levels. LPS-induced activation of p38 MAPK and NF- κB pathway was also suppressed. In conclusion, DNLA is effective in protecting against LPS-induced brain impairment, and this effect is due, at least in part, to prevent overexpression of TNFR1 via inhibition of p-p38 MAPK and the downstream NF- κB signal pathway.

Dendrobium Nobile Powder Extract and antioxidant activities

>In vitro antioxidant activities of a water-soluble polysaccharide derived from Dendrobium nobile Lindl. extracts.

(Source-College of Life Sciences, Sichuan University, Chengdu 610064, PR China.)

Abstract

A water-soluble polysaccharide (DNP), isolated from the aqueous extracts of the stem of Dendrobium nobile Lindl., was found to have an average molecular weight (Mw) of about 8.76 x 10(4)Da. Monosaccharides analysis revealed that DNP was composed of rhamnose, arabinose, xylose, mannose, glucose and galactose in a molar ratio of 1.00:2.80:2.20:30.76:117.96:31.76. The evaluation of antioxidant activity in vitro revealed that DNP is a novel potential antioxidant. The NMR spectra suggested that the main structure of DNP was possible as the predicted main structure of DNP from Dendrobium nobile, (fig. 5).

Dendrobium Nobile Powder Extract and anti-senescence activity

>Dendroflorin retards the senescence of MRC-5 cells.

(Source-Protein Science Key Laboratory of the Ministry of Education, Department of Biological Sciences and Biotechnology, School of Medicine, Tsinghua University, Beijing, People's Republic of China.)

 

Abstract

The influence of dendroflorin, a potentially active compound extracted from Dendrobium nobile, on cell growth and cell cycles was assessed in a human embryo lung fibroblastic MRC-5 cell line. An MTT assay indicated that dendroflorin benefits cell proliferation. Additionally, we used flow cytometry to examine the cell cycles in senescent MRC-5 cells after treatment with dendroflorin, discovering that dendroflorin could trigger cells in the G1 phase to enter the S phase. Further examination of intracellular ROS contents using DCFH-DA suggested that dendroflorin helps ROS degradation, partly elucidating the mechanism of its effects. All of the above results suggest that dendroflorin is a potential candidate with anti-senescence activity.

Side effects and safety of Dendrobium Nobile Powder Extract

Has not yet been reported that he has serious side effects.

Don't take advice pregnancy and breast-feeding

Dosage of Dendrobium Nobile Powder Extract

supplement:

Many Dendrobium Nobile Powder Extract 10:1 supplements recommend a dosage of around 1500 mg to 2000 mg

Company Information:

Nutragreen Biotechnology Co., Ltd, a brand of Shanghai Lvshang Biotech Co., Ltd, is a GMP compliant and FDA registered manufacturer and supplier of raw materials of plant extracts, botanicals, herbs, especially Tradtional Chinese herbs. Dendrobium Nobile Powder Extract is one of our most competitive ingredients with various specifications and stocks available all year round. You may leave a message below for more detailed information.