Red Bayberry Extract powder-US Stock available

• Product Detail

Product name	Red Bayberry Extract powder
Latin Name	Myrica rubra
Active ingredients	Myricetin
synonyms	Cannabiscetin, Myricetol, Myricitin
Appearance	Orange fine powder
Part used	Bark
Specification	Myricetin 50%,80% Min HPLC
Dosage
Main benefits	Antioxidant, anticancer, anti-diabetes, Brain health, antihypertensive
Applied industries	Medicine, food additive, dietary supplement, sports nutrition

 

What is Red Bayberry Extract powder?

Myricetin is a flavonoid that is commonly found in natural food sources such as berries, vegetables, teas, wine and herbs.

It is usually taken from the bark, leaves, and roots of the plant known as myrica cerifera.

Myricetin(Red Bayberry Extract powder) may have anti-inflammatory activity. In test tube studies, it has shown anti-tumor and antioxidant properties. It may also inhibit beta-amyloid fibril formation, a key problem with Alzheimer's disease. Flavonoids have antibacterial and antiviral activity.

Myricetin(Red Bayberry Extract powder) a wide variety of biological effects, including antioxidant and free radical-scavenging activities. Reports indicate that myricetin has anti-cancer and anti-inflammatory properties and may improve bone-health.

Benefits of taking Red Bayberry Extract powder supplements:

Myricetin(Red Bayberry Extract powder) and cancer

>Inhibitory effects of myricetin on mammalian DNA polymerase, topoisomerase and human cancer cell proliferation.

(Source-Laboratory of Food and Nutritional Sciences, Faculty of Nutrition, Kobe Gakuin University, Nishi-ku, Kobe, Hyogo 651-2180, Japan.)

Abstract

In this study, the inhibitory activities against mammalian DNA polymerases (pols) of 16 major bioflavonoids were investigated. Myricetin (3,3',4',5,5',7-hexahydroxyflavone) was the most potent inhibitor of pols amongst the compounds tested, with IC50 values of 21.3-40.9 μM. This compound did not affect the activities of plant (cauliflower) pol α or prokaryotic pols. Myricetin also inhibited human DNA topoisomerase II (topo II) activity with an IC50 value of 27.5 μM, but did not inhibit the activities of other DNA metabolic enzymes tested. Myricetin also did not influence the direct binding to double stranded DNA as determined by thermal transition analysis. It was found to prevent the proliferation of human colon HCT116 carcinoma cells with an LD50 of 28.2 μM, halt the cell cycle in G2/M phase, and induce apoptosis. These results suggest that the decrease of proliferation may be a result of the inhibition of cellular topoisomerase (topo) II rather than pols.

>Myricetin Induces Apoptosis in Hepg2 Cells through Akt/P70s6k/Bad Signaling and Mitochondrial Apoptotic Pathway.

(Source-Department of Food Science and Nutrition, School of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310029, P.R. China. )

Abstract

The present investigation was undertaken to gain insight into the molecular mechanism by which myricetin induces apoptosis in human hepatocarcinoma HepG2 cells. Myricetin caused the disruption of mitochondrial membrane potential in a dose-dependent manner. Moreover, myricetin triggered translocation of the pro-apoptotic protein Bax to the mitochondria, downregulation of anti-apoptotic Bcl-2 expression and upregulated the expression of pro-apoptotic protein Bad in the mitochondria. The present study also showed that myricetin promoted the release of cytochrome C from mitochondria into the cytosol followed by an increase in the proteolytic activation of caspase-3 and the concomitant degradation of PARP protein. Additionally, western blot analysis showed that the Akt/p70s6k1 pathway was inhibited in myricetin-treated HepG2 cells, accordingly the phosphorylation of Bad at Ser136 was downregulated. Collectively, these findings indicate that myricetin induced apoptosis in HepG2 cell through mitochondria apoptotic pathway and Akt/p70s6k1/Bad signaling. Present results provide new information on the possible mechanisms for the anti-cancer activity of myricetin.

Myricetin(Red Bayberry Extract powder) and diabetes

>Beneficial effect of myricetin on renal functions in streptozotocin-induced diabetes.

(Source-Department of Biochemistry, Faculty of Medicine, Akdeniz University, 07070 Antalya, Turkey.)

Abstract

Myricetin(Red Bayberry Extract powder) is a naturally occurring flavonoid that is known to decrease plasma glucose levels in diabetes; however, its influence on renal functions has not yet been determined. This study investigated the effect of myricetin on structural and functional changes occurring in diabetic nephropathy. Male Albino Wistar rats were divided into three groups: normoglycemic, diabetic and myricetin-treated diabetic. Diabetes was induced by intraperitoneal (ip) injection of streptozotocin (50 mg/kg), and rats having fasting blood glucose (FBG) levels greater than 200 mg/dl were included in the study. Treatment of myricetin (6 mg/day ip) was initiated 16 weeks after diabetes was confirmed. Light microscopy was performed on hematoxylin-eosin- and Masson's trichrome-stained sections to evaluate the effect of myricetin on structural changes in the kidney, while creatinine clearance, blood urea nitrogen (BUN), kidney weight, urine volume and protein were measured to assess kidney functions. Activities of glutathione peroxidase (GPx) and xanthine oxidase (XO) were also measured in renal tissues obtained from all experimental groups. Myricetin treatment significantly decreased glomerulosclerosis and reduced BUN, urinary volume and protein excretion, which was profoundly increased in diabetic rats. Decreased creatinine clearance measured in diabetic rats was significantly increased following myricetin treatment. Myricetin also restored altered renal activities of GPx and XO, which were decreased and increased in diabetic rats, respectively. In conclusion, myricetin improved altered renal functions and restored renal activities of GPx and XO in diabetic rats. Obtained data suggest that myricetin could be of therapeutic potential in diabetic nephropathy.

Myricetin(Red Bayberry Extract powder) and brain

Flavonoid Myricetin Modulates GABA(A) Receptor Activity through Activation of Ca(2+) Channels and CaMK-II Pathway.

(Source-Epithelial Cell Biology Research Centre, The Chinese University of Hong Kong, Hong Kong.)

Abstract

The flavonoid myricetin is found in several sedative herbs, for example, the St. John's Wort, but its influence on sedation and its possible mechanism of action are unknown. Using patch-clamp technique on a brain slice preparation, the present study found that Myricetin(Red Bayberry Extract powder) promoted GABAergic activity in the neurons of hypothalamic paraventricular nucleus (PVN) by increasing the decay time and frequency of the inhibitory currents mediated by GABA(A) receptor. This effect of myricetin was not blocked by the GABA(A) receptor benzodiazepine- (BZ-) binding site antagonist flumazenil, but by KN-62, a specific inhibitor of the Ca(2+)/calmodulin-stimulated protein kinase II (CaMK-II). Patch clamp and live Ca(2+) imaging studies found that myricetin could increase Ca(2+) current and intracellular Ca(2+) concentration, respectively, via T- and L-type Ca(2+) channels in rat PVN neurons and hypothalamic primary culture neurons. Immunofluorescence staining showed increased phosphorylation of CaMK-II after myricetin incubation in primary culture of rat hypothalamic neurons, and the myricetin-induced CaMK-II phosphorylation was further confirmed by Western blotting in PC-12 cells. The present results suggest that myricetin enhances GABA(A) receptor activity via calcium channel/CaMK-II dependent mechanism, which is distinctively different from that of most existing BZ-binding site agonists of GABA(A) receptor.

Myricetin(Red Bayberry Extract powder) and antioxidant

Improvement of Regio-Specific Production of Myricetin-3-O-α-L-Rhamnoside in Engineered Escherichia coli.

(Source-Department of Pharmaceutical Engineering, Institute of Biomolecule Reconstruction, Sun Moon University, #100, Kalsan-ri, Tangjeong-myeon, Asan-si, Chungnam, 336-708, Republic of Korea.)

Abstract

Myricetin(Red Bayberry Extract powder) is an important flavonol whose medically important properties include activities as an antioxidant, anticarcinogen, and antimutagen. The solubility, stability, and other biological properties of the compounds can be enhanced by conjugating aglycon with sugar moieties. The type of sugar moiety also plays a significant role in the biological and physical properties of the natural product glycosides. Reconstructed Escherichia coli containing thymidine diphosphate-α-L-rhamnose sugar gene cassette and Arabidopsis-derived glycosyltransferase were used for rhamnosylation of myricetin. Myricetin (100 μM) was exogenously supplemented to induced cultures of engineered E. coli. The formation of target product-myricetin-3-O-α-L-rhamnoside-was confirmed by chromatographic and NMR analyses. The yield of product was improved by using various mutants and methylated cyclodextrin as a molecular carrier for myricetin in combination with E. coli M3G3. The maximal yield of product is 55.6 μM (3.31-fold higher than the control E. coli MG3) and shows 55.6 % bioconversion of substrate under optimized conditions.

Myricetin(Red Bayberry Extract powder) and antihypertensive

Effect of Myricetin(Red Bayberry Extract powder) on blood pressure and metabolic alterations in fructose hypertensive rats.

Godse S, Mohan M, Kasture V, Kasture S.

Source

Department of Pharmacology, M.G.V.'s Pharmacy College, Panchavati, Nasik, Maharashtra, India.

Abstract

Fructose feeding induces a rise in blood pressure in normal rats and is associated with insulin resistance, hyperinsulinemia, and hypertriglyceridemia. We have examined the effect of myricetin (100 and 300 mg/kg, p.o. for 6 weeks) isolated from Vitis vinifera Linn. (Vitaceae) on systolic blood pressure (SBP), vascular reactivity, serum glucose, triglycerides, cholesterol, and insulin in fructose-induced hypertension. Myricetin reduced systolic blood pressure and vascular reactivity changes to catecholamines and reversed the metabolic alterations induced by fructose. The cumulative concentration-response curve (CCRC) of Ang II was shifted toward the right in rats treated with myricetin, using isolated strips of ascending colon. The results suggest that myricetin could prevent the development of high blood pressure induced by a diet rich in fructose, probably by reversing the metabolic alterations induced by fructose. In conclusion, Myricetin(Red Bayberry Extract powder) has antihypertensive action in the fructose model.

Side effects and safety of Red Bayberry Extract powder

Research does not indicate any side-effects on the intake of Myricetin. However, it would be considered wise to consult your health care provider, if you are on prescription drugs, or under care for any medical condition. Women who are nursing or are pregnant should also check with a doctor before using any supplements.

Dosage of Red Bayberry Extract powder

supplement:

On the mechanism of antiaggregatory effect of myricetin.

(Source-Department of Pharmacology, N. Copernicus Academy of Medicine, Kraków, Poland.)

Abstract

Myricetin(Red Bayberry Extract powder) at a dose of 3.6 micrograms/kg iv was found to inhibit the cat blood platelet aggregation in vivo. It disaggregated platelet thrombi in vitro at a concentration of 60 nM. This flavonoid bound to platelet membranes and prevented prostacyclin synthase against oxygen free radicals owing to its antioxidant properties. Myricetin inhibited soybean lipoxygenase when linoleic acid was used as a substrate.