Rhizoma Polygonati(Huang Jing) Extract powder

• Product Detail

Product name	Rhizoma Polygonati(Huang Jing) Extract powder
Latin Name	Polygonatum sibiricum Delar. ex Redoute
Active ingredients	anthraquinone compounds etc.
synonyms	Huang Jing, Manyflower Solomonseal Rhizome，Siberian Solomonseal Rhizome，King Solomonseal Rhizome
Appearance	Brown fine powder
Part used	Root
Specification	5:1 10:1 20:1
Dosage	1500-2000mg daily
Main benefits	anti-inflammatory, anti-diabetes, Cardiovascular disease
Applied industries	Medicine, food additive, dietary supplement, sports nutrition

What is Rhizoma Polygonati(Huang Jing) Extract powder?

Also known as Solomon's seal, polygonatum is a perennial herb that belongs to the lily family. It is native to east Asia and can be found throughout China, particularly in the Henan, Jiangsu, Zhejiang and Fujian provinces.

The part of the plant used in herbal preparations is the rhizome, which is harvested in the spring and autumn, then dried and sliced. It can be used unprepared or steamed, and is often steamed with other items, such as wine and black beans.

The sweet and slightly bitter herb has been used in TCM to lower blood lipids, treat arteriosclerosis, lower blood pressure, etc., as it nourishes Yin, moistens the Lungs, promotes generation of Body Fluids. nourishes the Stomach, etc., by enhancing the functions of lung and stomach channels.

Chemical constituents of Rhizoma Polygonati(Huang Jing) Extract powder

Rhizoma Polygonati contains Azetidine - 2 - carboxylic acid, Aspartic acid, Homoserine, Diaminobutyric acid, Digitalis glycoside, and a variety of anthraquinone compounds.

Benefits of taking Rhizoma Polygonati(Huang Jing) Extract powder supplements:

Rhizoma Polygonati(Huang Jing) and Diabetes

>Antihyperglycemic effects of total flavonoids from Polygonatum odoratum in STZ and alloxan-induced diabetic rats.

(Source-College of Biology & Chemistry Engineering, Changsha University of Science & Technology, Changsha 410076, PR China. )

Abstract

AIM OF THE STUDY:

Total flavonids of Polygonatum(P) odoratum (TFP) were tested for anti-diabetic activity in streptozotocin (STZ)-induced diabetic mice and alloxan-induced diabetic rats.

MATERIALS AND METHODS:

Rhizoma Polygonati Odorati, well-known Chinese traditional medicine, is widely used for treatment of diverse diseases for example diabetes. In our study, TFP was extracted by 70% ethanol and purified by macroreticular resin. The experiments were designed to detect the anti-diabetic activity of TFP by determination of blood glucose (BG) using one touch gluco-meter and insulin levels by using a radioimmunoassay kit in streptozotocin (STZ)-induced diabetic mice and alloxan-induced diabetic rats and alpha-amylase inhibitory activity by alpha-amylase inhibition assay in vitro.

RESULTS:

TFP had beneficial effects on regulation of blood glucose. Daily administration with 50-200 mg/kg body weight of TFP for 9 days can reduce significantly hyperglycemia in STZ-induced diabetic mice. Thirtieth day administration with TFP (50-200 mg/kg body weight) also decreased significantly fasting blood glucose in alloxan-induced diabetic rats. The hypoglycemic effect of TFP at 50 and 100 mg/kg is less than that of acarbose 20 mg/kg and gliclazide 15 mg/kg. The hypoglycemic effects of TFP at 200 mg/kg is similar to that of acarbose 20 mg/kg and gliclazide 15 mg/kg. TFP also could increase significantly the insulin level in alloxan-induced type 2 diabetic rats (P<0.05) compared with control. Alpha-amylase inhibition assay in vitro showed that TFP inhibited significantly alpha-amylase activity in a dose-dependent manner.

CONCLUSIONS:

TFP possess significant dose-dependent anti-diabetic activity. TFP is one of the primary hypoglycemic active compounds of Polygonatum odoratum which would worth further study and development.

Rhizoma Polygonati(Huang Jing) and anti-adipogenic

>Negative regulation of adipogenesis by kaempferol, a component of Rhizoma Polygonati falcatum in 3T3-L1 cells.

Park UH, Jeong JC, Jang JS, Sung MR, Youn H, Lee SJ, Kim EJ, Um SJ.

Source

Department of Bioscience and Biotechnology, Sejong University, Seoul, Korea.

Abstract

Rhizoma Polygonati falcatum (RPF) has been used as a traditional herbal medicine in Asia, because of its anti-hyperglycemic, anti-triglycemic, and anti-tumor activity. In this study, we determined the anti-adipogenic potential of RPF extract and its component kaempferol in 3T3-L1 adipocytes, and the underlying molecular mechanism(s) using microarray analysis. Adipocyte differentiation of 3T3-L1 cells was significantly impaired by RPF extract and kaempferol as monitored by Oil Red O staining and quantitative measurement of lipid accumulation. Additionally, the mRNA expression of adipogenesis genes decreased on treatment with kaempferol. The role of kaempferol at the genome-wide level was further assessed by a microarray approach. Our analysis indicated that kaempferol decreased the expression of adipogenic transcription factors (Pparγ, Cebpβ, Srebp1, Rxrβ, Lxrβ, Rorα) and genes involved in triglyceride biosynthesis (Gpd1, Agpat2, Dgat2), while increasing lipolysis-related genes, such as Tnfα, Lsr, and Cel. Finally, co-transfection assays using luciferase reporter gene and reverse transcription-polymerase chain reaction (RT-PCR) analysis using peroxisome proliferator-activated receptor-γ (PPARγ) target genes indicated that kaempferol significantly repressed rosiglitazone-induced PPARγ transcriptional activity. Overall, our data suggests that kaempferol, a major component of RPF, may be beneficial in obesity, by reducing adipogenesis and balancing lipid homeostasis partly through the down-regulation of PPARγ.

Rhizoma Polygonati(Huang Jing) and anti-inflammatory

>Effect of Rhizoma Polygonati on 12-O-tetradecanoylphorbol-acetate-induced ear edema in mice.

Xian YF, Lin ZX, Xu XY, Su ZR, Chen JN, Lai XP, Ip SP.

(Source-School of Chinese Medicine, The Chinese University of Hong Kong, Hong Kong SAR, PR China.)

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE:

Rhizoma Polygonati is originated from the dried rhizomes of Polygonatum sibircum Red. It has long been used in traditional Chinese medicine for the treatment of inflammatory disorders.

AIM OF THE STUDY:

The present study aims to investigate the anti-inflammatory effect of aqueous extract of Rhizoma Polygonati (ERP) in a mouse model of inflammation induced by 12-O-tetradecanoylphorbol-acetate (TPA).

MATERIALS AND METHODS:

The anti-inflammatory effect was evaluated by measuring the ear thickness and activity of myeloperoxidase (MPO). The anti-inflammatory mechanism was explored by determining the protein and mRNA levels of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, and IL-6.

RESULTS:

The results showed that ERP significantly decreased the ear thickness and MPO activity in mouse model of inflammation induced by TPA. In addition, ERP also remarkably inhibited the protein and mRNA levels of iNOS, COX-2, TNF-α, IL-1β, and IL-6.

CONCLUSIONS:

These results indicate that ERP has potential anti-inflammatory effect on TPA-induced inflammatory in mice, and the anti-inflammatory effect may be mediated, at least in part, by inhibiting the mRNA expression of a panel of inflammatory mediators including iNOS, COX-2, TNF-α, IL-1β, and IL-6.

Other use

>anti-hyperglycemic

>anti-triglycemic

> anti-tumor

Side effects and safety of Rhizoma Polygonati(Huang Jing) Extract powder

There is no report that it has a serious side effects.

Dosage of Rhizoma Polygonati(Huang Jing) Extract powder supplement:

Many Rhizoma Polygonati(Huang Jing) Extract powder10:1 supplements recommend a dosage of around 1500 mg to 2000 mg.

Consult your physician if you have any questions about the proper use of Rhizoma Polygonati(Huang Jing) Extract powder supplements.

Company Information:

Nutragreen Biotechnology Co., Ltd, a brand of Shanghai Lvshang Biotech Co., Ltd, is a GMP compliant and FDA registered manufacturer and supplier of raw materials of plant extracts, botanicals, herbs, especially Tradtional Chinese herbs. Rhizoma Polygonati(Huang Jing) Extract powder is one of our most competitive ingredients with various specifications and stocks available all year round. You may leave a message below for more detailed information.