Senna Leaf Extract powder

• Product Detail

Product name	Senna Leaf Extract powder
Latin Name	Cassia angustifolia Vahl
Active ingredients	Sennosides
synonyms	Alexandrian Senna, Alexandrinische Senna, Casse, Cassia acutifolia, Cassia angustifolia, Cassia lanceolata, Cassia senna, Fan Xie Ye, Indian Senna, Khartoum Senna, Sen, Sena Alejandrina, Séné, Séné d'Alexandrie, Séné d'Egypte, Séne d’Inde, Séné de Tinnevelly, Senna alexandrina, Sennae Folium, Sennae Fructus, Sennosides, Tinnevelly Senna, True Senna.
Appearance	Brown yellow fine powder
Part used	Leaf
Specification	Sennosides（A+B ）5.5% HPLC/Sennosides 3%-20% UV
Dosage
Main benefits	Constipation, Weight loss
Applied industries	Medicine, food additive, dietary supplement, sports nutrition

What is Senna Leaf Extract powder?

Senna Leaf is commonly known as senna or Alexandrian senna, and its scientific name is Cassia angustifolia. Senna has been used since the 9th century by Arabian physicians as a laxative and has been known as the "cleansing herb." "Only the leaves and the pods of the herb are therapeutically useful," states Herbs 2000. Senna is often taken as a tea, capsule, tablet or liquid extract.

Senna leaf acts on the intestinal walls, causing contractions that lead to bowel movements. In this regard, it can be used to effectively relieve even the most severe cases of constipation. Because of its glycoside content, which helps transport electrolytes, it helps to cleanse the colon creating a bowel movement that usually occurs within six to 12 hours after it is taken. According to Traditional Chinese Medicine, or TCM, senna leaf, also called Fan Xie Ye, helps to clear away heat accumulated in the large intestine, helping rid the body of stagnant food that has accumulated in the organs. Considered sweet, bitter, and cold in nature, it is not to be used during pregnancy or menstruation or by nursing mothers.

Chemical constituents of Senna Leaf Extract powder

Senna Leaf Extract usually include Sennoside A，sennoside B，sennoside C，sennoside D， crysophanol， emodin， physcion， tinnevellinglucoside.

Benefits of taking Senna Leaf Extract powder supplements:

Senna acts as a laxative and is primarily used for constipation, preoperative cleansing and weight loss, and may also help with hypertension. Senna can also be used as an anti-inflammatory, for cellular regeneration, and to treat anal fissures and hemorrhoids. As a paste, senna can be used to treat acne, ringworm and other skin disorders.

Constipation

There are many studies support senna laxative effect. The following is one of the typical research.

>The influence of rhein 8-O-β-D-glucopyranoside on the purgative action of sennoside A from rhubarb in mice.（Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, 1 Sanzo, Gakuen-cho, Fukuyama, Hiroshima 729–0292, Japan.）

Abstract

Rhubarb is one of the most well-known herbal medicines that constitute daiokanzoto (DKT), which is clinically effective for constipation. Sennoside A is transformed into an active metabolite, rheinanthrone, by intestinal bacteria. Sennoside A in rhubarb showed significantly accelerated metabolic activity in intestinal bacteria in comparison with sennoside A alone. In this study, we investigated the influence of rhubarb constituents on the metabolism and purgative activity of sennoside A. The 20% MeOH-eluted fraction separated by MCI-gel CHP-20P column chromatography from the water extract of rhubarb showed sennoside A metabolic activity similar to that of rhubarb extract. The 20% MeOH elute was further purified and rhein 8-O-β-D-glucopyranoside (RG) was isolated. The metabolic activity of sennoside A was significantly accelerated by increasing the level of RG. Moreover, rhein, emodin and aloe-emodin also accelerated sennoside A metabolism. The purgative activity of sennoside A was significantly accelerated when RG or rhein was concomitantly given with sennoside A in a dose-dependent manner. These results suggest that anthraquinones contribute to the purgative action of sennoside A in rhubarb. Therefore, it is assumed that the influence of anthraquinones on the fate of rheinanthrone transformed from sennoside A may promote the purgative action of sennoside A.

Weight loss

According to Traditional Chinese Medicine, or TCM, senna leaf, also called Fan Xie Ye, helps to clear away heat accumulated in the large intestine, helping rid the body of stagnant food that has accumulated in the organs.

Senna contains glycosides, which are a group of organic compounds that are commonly found in plants. These compounds work as a laxative by smoothing the muscles as digested food moves through the intestines. This helps to enhance the stool volume and move it out of the colon. The process is caused by the chain of fatty acids that promote digestion, fermentation, and successfully converting the glycosides into a purgative agent.

Colon cancer

>Usefulness of sennoside as an agent for mechanical bowel preparation prior to elective colon cancer surgery.（Department of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University, Kawagoe, Saitama, Japan.）

OBJECTIVE:

We retrospectively evaluated the usefulness of sennoside as an agent for mechanical bowel preparation prior to elective colon cancer surgery.

METHODS:

A total of 86 patients were given 12 mg of sennoside on the evening prior to resective surgery for colon cancer, followed by intravenous antimicrobial prophylaxis used on the day of surgery or until postoperative day 2.

RESULTS:

The incidence of surgical site infection in the study group was 4.7%, which was comparable to that in the historical control patients (3.5%, p>0.99), who had received polyethylene glycol for mechanical bowel preparation prior to colon surgery. On multivariate logistic regression analysis, only body mass index (p=0.04) was an independent significant factor affecting the surgical site infection. The intraoperative spillage was not influenced by the presence of stenosis, although the amount of fecal matter was higher in the upstream colon segment (p<0.01) and downstream segment (p=0.07) in patients with a stenotic lesion occupying more than two-thirds of the lumen (n=29) than in those without such severe stenosis (n=57).

CONCLUSION:

Sennoside seems to be an acceptable agent for mechanical bowel preparation even in patients with stenosis.

Side effects and safety of Senna Leaf Extract powder

Senna is LIKELY SAFE for most adults and children over age 2 when used short-term. Senna is an FDA-approved nonprescription medicine. Senna can cause some side effects including stomach discomfort, cramps, and diarrhea.

Drink eight 6-oz cups of water along with senna to avoid dehydration. Senna should not be taken for more than 10 days without a period of rest to maintain health.

Senna is not recommended when abdominal pain, nausea, or vomiting, or a sudden change in bowel habits are present. Long-term administration of senna is not recommended for the treatment of chronic constipation. Rectal bleeding or failure to have a bowel movement after senna use may indicate a serious underlying gastrointestinal condition, and warrants discontinuation of therapy and evaluation.

Dosage of Senna Leaf Extract powder supplement:

As a tea, two cups should be drunk daily. A daily dose of 10 to 60mg of senna is recommended for adults, and half doses are recommended for children aged six and up.

Consult your physician if you have any questions about the proper use of Senna Leaf Extract powder supplements.