Kava Powder Extract

• Product Detail

Product name	Kava Powder Extract
Latin Name	Piper Methysticum L.
Active ingredients	Kavalactones
synonyms	Ava Pepper, Ava Root, Awa, Gea, Gi, Intoxicating Long Pepper, Intoxicating Pepper, Kao, Kavain, Kavapipar, Kawa, Kawa Kawa, Kawa Pepper, Kawapfeffer, Kew, Lawena, Long Pepper, Malohu, Maluk, Maori Kava, Meruk, Milik, Piper methysticum, Poivre des Cannibales, Poivre des Papous, Rauschpfeffer, Rhizome Di Kava-Kava, Sakau, Tonga, Waka, Wurzelstock, Yagona, Yangona, Yaqona, Yaquon, Yongona.
Appearance	Light brown fine powder
Part used	Root
Specification	Kavalactones 5% -30%
Dosage	240-480mg daily
Main benefits	Antianxiety, Insomnia
Applied industries	Medicine, food additive, dietary supplement, sports nutrition

What is Kava Powder Extract?

Kava is a tall shrub that grows in the islands of the Pacific Ocean. In Fiji, the plant is called "yaquona," in Hawaii, it's known as "awaj," and in Aboriginal tribes, it's referred to as "grog." This shrub produces large, green, heart shaped leaves that grow thickly on the branches. Long, slender flowers grow where the branches meet the stems. The roots look like bundles of woody, hairy branches. The root is the part of the plant used medicinally.

Kava is also known as Piper methysticum, awa, kava-kava, kew, tonga, ava, ava pepper, intoxicating pepper, kawa, kava pepper, kava root, rauschpfeffer, sakau, tonga, wurzelstock, and yangona.

Kava has been used to induce and improve sleep, and to decrease anxiety, nervousness, stress, and restlessness.

Chemical constituents of Kava Powder Extract

Kava's active principal ingredients are the kavalactones, of which at least 15 have been identified and are all considered psychoactive. Only six of them produce noticeable effects, and their concentrations in kava plants vary.

Kavalactones contained in the resin are α-pyrones bearing a methoxyl group at C-4 and an aromatic styryl moiety at C-6. They include kavain, 7,8-dihydrokavain, 5,6-dehydrokavain, yangonin, 5,6,7,8-tetrahydroyangonin, methysticin, dihydromethysticin, 5,6-dehydromethy sticin, 5,6-dihydroyangonin, 7,8-dihydroyangonin, 10-methoxy-yangonin, 11-methoxy-yangonin, 11-hydroxy-yangonin, hydroxykavain, and 11-methoxy-l2-hydroxy-dehydrokavain, and 11-methoxy-5,6-dihydroyangonin.

The rootstock also contains flavokavins A–C; piperidine alkaloids pipermethystin, cepharadione A, and awaine; ketones including cinnamalaketone and methylenedioxy-3,4-cinnamalaketone; an alcohol, dihydrokavain-5-ol; minerals including potassium, calcium, magnesium, sodium, aluminum, iron, and silica; sugars include saccharose, maltose, fructose, and glucose; over 15 amino acids; and others.

Benefits of taking Kava Powder Extract

supplements:

Kava and anxiety

>Kava in the treatment of generalized anxiety disorder: a double-blind, randomized, placebo-controlled study.

(Source-Department of Psychiatry, University of Melbourne, Melbourne, Victoria, Australia. )

Abstract

Kava (Piper methysticum) is a plant-based medicine, which has been previously shown to reduce anxiety. To date, however, no placebo-controlled trial assessing kava in the treatment of generalized anxiety disorder (GAD) has been completed. A total of 75 participants with GAD and no comorbid mood disorder were enrolled in a 6-week double-blind trial of an aqueous extract of kava (120/240 mg of kavalactones per day depending on response) versus placebo. γ-Aminobutyric acid (GABA) and noradrenaline transporter polymorphisms were also analyzed as potential pharmacogenetic markers of response. Reduction in anxiety was measured using the Hamilton Anxiety Rating Scale (HAMA) as the primary outcome. Intention-to-treat analysis was performed on 58 participants who met inclusion criteria after an initial 1 week placebo run-in phase. Results revealed a significant reduction in anxiety for the kava group compared with the placebo group with a moderate effect size (P = 0.046, Cohen d = 0.62). Among participants with moderate to severe Diagnostic and Statistical Manual of Mental Disorders-diagnosed GAD, this effect was larger (P = 0.02; d = 0.82). At conclusion of the controlled phase, 26% of the kava group were classified as remitted (HAMA ≤ 7) compared with 6% of the placebo group (P = 0.04). Within the kava group, GABA transporter polymorphisms rs2601126 (P = 0.021) and rs2697153 (P = 0.046) were associated with HAMA reduction. Kava was well tolerated, and aside from more headaches reported in the kava group (P = 0.05), no other significant differences between groups occurred for any other adverse effects, nor for liver function tests. Standardized kava may be a moderately effective short-term option for the treatment of GAD. Furthermore, specific GABA transporter polymorphisms appear to potentially modify anxiolytic response to kava.

Kava and Cancer

Flavokawain B, a kava chalcone, inhibits growth of human osteosarcoma cells through G2/M cell cycle arrest and apoptosis.

(Source-Department of Orthopaedic Surgery, UC Irvine Multidisciplinary Sarcoma Center, Chao Family Comprehensive Cancer Center, University of California, Irvine, USA.)

Abstract

BACKGROUND:

Osteosarcoma (OS) is the most common primary bone malignancy with a high propensity for local invasion and distant metastasis. Limited by the severe toxicity of conventional agents, the therapeutic bottleneck of osteosarcoma still remains unconquered. Flavokawain B (FKB), a kava extract, has been reported to have significant anti-tumor effects on several carcinoma cell lines both in vitro and in vivo. Its efficacy and low toxicity profile make FKB a promising agent for use as a novel chemotherapeutic agent.

RESULTS:

In the current study, we investigated the anti-proliferative and apoptotic effects of FKB against human osteosarcomas. Exposure of OS cells to FKB resulted in apoptosis, evidenced by loss of cell viability, morphological changes and the externalization of phosphatidylserine. Apoptosis induced by FKB resulted in activation of Caspase-3/7, -8 and -9 in OS cell lines, 143B and Saos-2. FKB also down-regulated inhibitory apoptotic markers, including Bcl-2 and Survivin and led to concomitant increases in apoptotic proteins, Bax, Puma and Fas. Therefore, the induction of apoptosis by FKB involved both extrinsic and intrinsic pathways. FKB also caused G2/M phase cell cycle arrest, which was observed through reductions in the levels of cyclin B1, cdc2 and cdc25c and increases in Myt1 levels. Furthermore, migration and invasion ability was decreased by FKB in a dose-dependent manner. The cytotoxicity profile showed FKB had significant lower side effects on bone marrow cells and small intestinal epithelial cells compared with Adriamycin.

CONCLUSIONS:

Taken together, our evidence of apoptosis and cell cycle arrest by FKB treatment with less toxicity than the standard treatments provides an innovative argument for the use of FKB as a chemotherapeutic and chemopreventive compound. In vivo experiments utilizing FKB to reduce tumorigenesis and metastatic potential will be crucial to further justify clinical application.

Other use

>Anxiety.

>Anxiety in women going through menopause.

>Stress,

>insomnia

>psychosis

>depression

>headaches

>chronic bladder infections

Side effects and safety of Kava Powder Extract

Stop taking kava and seek emergency medical attention if you have liver symptoms such as nausea, stomach pain, loss of appetite, itching, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes).

Dosage of Kava Powder Extract supplement:

Many Kava Powder Extract supplements recommend a dosage of around 240 mg to 480 mg.

Consult your physician if you have any questions about the proper use of Kava Powder Extract supplements.

Company Information:

Nutragreen Biotechnology Co., Ltd, a brand of Shanghai Lvshang Biotech Co., Ltd, is a GMP compliant and FDA registered manufacturer and supplier of raw materials of plant extracts, botanicals, herbs, especially Tradtional Chinese herbs. Kava Powder Extract is one of our most competitive ingredients with various specifications and stocks available all year round. You may leave a message below for more detailed information.