Yeast Extract

• Product Detail

Product name	Yeast Extract
Active ingredients	Beta Glucan
synonyms	(1,3) Beta glucan, Beta glucan
Appearance	Brown fine powder
Specification	Beta Glucan 50% 70% 80%,85%
Dosage	200-600mg daily
Main benefits	immune function
Applied industries	Medicine, food additive, dietary supplement, sports nutrition

What is Yeast Extract?

Yeast is a single cell micro-organism (fungus) that converts sugar and starch into carbon dioxide bubbles and alcohol.

A common method for making yeast extract for supplements or food products, such as Vegemite and Marmite, is to add salt to a suspension of yeast. The yeast cells shrivel up and start to break down, especially once heat is added. The thick cell walls of the yeast are then removed, which leaves the nutrient-rich contents of the cells. The processed extract is a very good source of protein, vitamins and minerals.

Chemical constituents of Yeast Extract

Main ingredients for polypeptide, amino acid, flavor nucleotides, B vitamins and trace microelements.

Health food field general extracting Beta Glucan.

How does work Yeast Extract Beta Glucan?

In one research effort, it was found that yeast (1,3) Beta glucan binds directly to the Dectin-1 receptor on macrophages, giving us our first line of defense against dangerous bacteria and other health challenges. Dectin-1 is believed to be how Beta glucan is taken up into the body in the intestinal tract, as well as how it activates the macrophage to do its job as a molecular scavenger. This would make yeast Beta glucan extremely effective in helping the body fight off infection and/or help macrophages clear out abscesses or dead cells.

There is another receptor, the CR3 receptor on leukocytes, which helps fight infections and tumors by binding to antibodies along with Beta glucan in such a way that both must be bound for an effect to take place. When Beta glucan and the antibody attach to the CR3 receptor on leukocytes, the result is a destruction of a particular pathogen or tumor cell.

Benefits of taking Yeast Extract supplements:

Yeast Extract and immune functions

>Hot water extract of the sclerotium of Polyporus rhinocerus Cooke enhances the immune functions of murine macrophages.

(Source-School of Life Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China.)

Abstract

Treatment of hot water extract of the sclerotium of Polyporus rhinocerus (PRW) with murine macrophages including RAW 264.7 cell line and primary macrophages (PMs) could enhance their functional activities. These include a significant up-regulation of pinocytosis; an increase in the production of reactive oxygen species (ROS) and nitric oxide (NO); an increase in tumor necrosis factor alpha (TNF-alpha) production and inducible nitric oxide synthase (iNOS) expression in both RAW 264.7 cells and PMs. Cell surface receptors for yeast-derived beta-glucan, including Dectin-1, CR3, and TLR2, were determined by flow cytometry, and the expression of Dectin-1+ cells on the cell surface decreased in the responses of PMs to PRW. PRW increased phosphorylation of IkappaBalpha, which could trigger the nuclear factor kappa B (NF-kappaB) signal pathway for macrophage activation in RAW 264.7 cells. Therefore, the immunomodulatory effect of PRW could be mediated by macrophage activation via the NF-kappaB signal pathway.

> Zymosan activates protein kinase A via adenylyl cyclase VII to modulate innate immune responses during inflammation.

(Source-Department of Pharmacology, UT Southwestern Medical Center, Dallas, TX 75390-9041, United States.)

Abstract

Pathogens use a variety of strategies to evade host immune defenses. A powerful way to suppress immune function is to increase intracellular concentrations of cAMP in host immune cells, which dampens inflammatory responses and prevents microbial killing. We found that the yeast cell wall extract, zymosan, is capable of increasing intracellular cAMP and activates the protein kinase A pathway in bone marrow derived macrophage (BMDM) cells from mice. This response is dependent on adenylyl cyclase type VII (AC7) and heterotrimeric G proteins, primarily G(12/13). Consequently, zymosan induced production of the inflammatory cytokine, TNFα, was much stronger in BMDMs from AC7 deficient mice compared to the response in wild type cells. In a model of zymosan induced peritonitis, mice deficient of AC7 in the myeloid lineage displayed prolonged inflammation. We propose that zymosan induced increases in cAMP and activation of PKA serve as a mechanism to dampen inflammatory responses in host cells, which consequently favors the survival of microbes. This would also help explain a well documented phenomenon, that the ability of zymosan to stimulate inflammatory cytokine responses via TLR2 appears to be weaker than other stimuli of TLR2.

Side effects and safety of Yeast Extract

There is no report that it has a serious side effects.

Dosage of Yeast Extract supplement:

Many artichoke supplements recommend a dosage of around 200 mg to 600 mg

Consult your physician if you have any questions about the proper use of Yeast Extract supplements.

Company Information:

Nutragreen Biotechnology Co., Ltd, a brand of Shanghai Lvshang Biotech Co., Ltd, is a GMP compliant and FDA registered manufacturer and supplier of raw materials of plant extracts, botanicals, herbs, especially Tradtional Chinese herbs. Yeast Extract is one of our most competitive ingredients with various specifications and stocks available all year round. You may leave a message below for more detailed information.