Sage extract powder

• Product Detail

Product name	Sage extract powder
Latin Name	Salvia Officinalis
Active ingredients
synonyms	Common Sage, Dalmatian Sage, Feuille de la Bergère, Garden Sage, Herbe Sacré, Meadow Sage, Salvia lavandulaefolia, Salvia officinalis, Sauge, Sauge Ananas, Sauge des Prairies, Sauge Divinatoire, Sauge Divine, Sauge Domestique, Sauge Officinale, Scarlet Sage, Spanish Sage, True Sage, Vraie Sauge.
Appearance	Brown  fine powder
Part used	Seed & Leaf
Specification	10:1,20;1
Dosage
Main benefits	Anti -inflammatory , Anti-bacterial, Cancer, Diabetes
Applied industries	Medicine, food additive, dietary supplement

 

What is Sage?

Sage(Salvia Officinalis) is a small, perennial, evergreen sub shrub, with woody stems, greyish leaves, and blue to purplish flowers. It is a member of the family Lamiaceae and is native to the Mediterranean region, though it has naturalized in many places throughout the world.

Its use in history dates back to the ancient Greek times where this herb was used for copious ailments (examples include and are definitely not limited to insomnia, measles, seasickness, venereal disease and worms). Physicians in ancient Greece used a solution of sage and water to stop wounds from bleeding and to clean sores and ulcers.

According to traditional Chinese medicine, be used for clearing heat and promoting diuresis, promoting blood circulation to restore menstrual flow, detumescence by detoxification.

Chemical constituents of Sage extract powder

Sage contains a variety of antioxidants — in the form of volatile oils, flavonoids and phenolic acids. Sage also contains antioxidant enzymes, including superoxide dismutase and peroxidase.

The strongest active constituents of sage are within its essential oil, which contains cineole, borneol, and thujone. Sage leaf contains tannic acid, oleic acid, ursonic acid, ursolic acid, cornsole, cornsolic acid, fumaric acid, chlorogenic acid, caffeic acid, niacin, nicotinamide, flavones, flavonoid glycosides, and estrogenic substances.

Benefits of taking Sage extract powder supplements:

Anti -inflammatory and Anti-bacterial

> Antibacterial, allelopathic and antioxidant activities of essential oil of Salvia officinalis L. growing wild in the Atlas Mountains of Morocco.

Source

a Laboratoire de Chimie Organique Appliquée, Equipe Analyse et Contrôle de Qualité, Faculté des Sciences Semlalia, Université Cadi Ayyad , BP 2390 Bd. Prince Moulay Abdallah , Marrakech , 40100 , Morocco.

Abstract

Salvia officinalis (Common sage, Culinary sage) is an aromatic plant that is frequently used as a spice in Mediterranean cookery and in the food industry and as a traditional medicine for the treatment of several infectious diseases. The essential oils were obtained by two different methods [hydrodistillation (HD) and microwave (Mw)] from the aerial part of S. officinalis L. growing wild in Ourika - Marrakech in Morocco. Ourika is a large zone of the Atlas Mountains which is considered as a large reserve of Flora, especially medicinal and aromatic plants. The obtained oils were analysed by gas chromatography and gas chromatography-mass spectrometry and compared with that of Tunisia. Thirty-six compounds were identified from the Mw-extracted oil which accounted for 97.32% of the total oil composition. However, 33 compounds obtained by HD representing 98.67%. The major components were trans-thujone (14.10% and 29.84%), 1,8-cineole (5.10% and 16.82%), camphor (4.99% and 9.14%), viridiflorol (16.42% and 9.92%), β-caryophyllene (19.83% and 5.20%) and α-humulene (13.54% and 4.02%). Antibacterial, allelopathic (% germination in lettuce seeds and inhibited root growth obtained after treatment with S. officinalis oils) and antioxidant (IC50 values 22 mg/mL) activities were studied

Cancer

>Sage components enhance cell death through nuclear factor kappa-B signaling.

Source

Department of Biology, American University of Beirut, Beirut, Lebanon.

Abstract

The sage components linalyl acetate (Ly) and alpha-terpineol (Te) exhibit synergistic anti-proliferative effects. We investigated the effects of Ly and Te on NF-kappaB signaling in HCT-116 colon cancer cells. Ly and Te combinations dose-dependently reduced HCT-116 viability at non-cytotoxic concentrations. Combination treatment induced 30%-60% increase in PreG1 through induction of apoptosis and necrosis. DNA binding assays revealed that combination treatment suppressed both basal and TNF-alpha-induced NF-kappaB activation. This suppression correlated with the inhibition of p65 nuclear translocation and IkappaB-alpha degradation. The lack of change in IKK expression levels or inhibition in IkappaB-alpha phosphorylation suggest the involvement of an IKK-independent mechanism. Ly and Te combination was found to downregulate the expression of NF-kappaB-regulated antiapoptotic and proliferative gene products. Separate treatments and drug combinations significantly decreased DNA binding activity of NF-kappaB which led to the potentiation of cell death induced by the colon cancer drugs oxaliplatin and 5-FU. These results indicate that Ly and Te anticancer activities are partly mediated through the suppression of NF-kappaB activation, suggesting their use in combination with chemotherapeutic agents to induce apoptosis.

>Sage components enhance cell death through nuclear factor kappa-B signaling.

Deeb SJ, El-Baba CO, Hassan SB, Larsson RL, Gali-Muhtasib HU.

Source

Department of Biology, American University of Beirut, Beirut, Lebanon.

Abstract

The sage components linalyl acetate (Ly) and alpha-terpineol (Te) exhibit synergistic anti-proliferative effects. We investigated the effects of Ly and Te on NF-kappaB signaling in HCT-116 colon cancer cells. Ly and Te combinations dose-dependently reduced HCT-116 viability at non-cytotoxic concentrations. Combination treatment induced 30%-60% increase in PreG1 through induction of apoptosis and necrosis. DNA binding assays revealed that combination treatment suppressed both basal and TNF-alpha-induced NF-kappaB activation. This suppression correlated with the inhibition of p65 nuclear translocation and IkappaB-alpha degradation. The lack of change in IKK expression levels or inhibition in IkappaB-alpha phosphorylation suggest the involvement of an IKK-independent mechanism. Ly and Te combination was found to downregulate the expression of NF-kappaB-regulated antiapoptotic and proliferative gene products. Separate treatments and drug combinations significantly decreased DNA binding activity of NF-kappaB which led to the potentiation of cell death induced by the colon cancer drugs oxaliplatin and 5-FU. These results indicate that Ly and Te anticancer activities are partly mediated through the suppression of NF-kappaB activation, suggesting their use in combination with chemotherapeutic agents to induce apoptosis.

Diabetes

>Improved glycemic control and lipid profile in hyperlipidemic type 2 diabetic patients consuming Salvia officinalis L. leaf extract: A randomized placebo. Controlled clinical trial.

Source

Department of Pharmacology and Applied Medicine, Research Institute of Medicinal Plants, ACECR, Karaj, Iran.

Abstract

OBJECTIVES:

Evaluation of the efficacy and safety of Salvia officinalis L. (S. officinalis) leaf extract in the treatment of hyperlipidemic type 2 diabetic patients.

MAIN OUTCOME MEASURES:

Fasting blood levels of glucose, glycosylated hemoglobin (HbA1c), total cholesterol, triglyceride, LDL-C (low density lipoprotein cholesterol), HDL-C (high density lipoprotein cholesterol), SGOT (serum glutamic-oxaloacetic transaminase), SGPT (serum glutamic-pyruvic transaminase) and creatinine.

RESULTS:

The extract lowered fasting glucose, HbA1c, total cholesterol, triglyceride and LDL-C but increased HDL-C compared to baseline at endpoint. Percent difference mean (95% confidence interval) between the extract and placebo groups in terms of effects on fasting glucose, HbA1c, total cholesterol, triglyceride, LDL-C and HDL-C at endpoint were 32.2 (26.5, 37.9), 22.7 (16.8, 28.6), 16.9 (9.7, 24.1), 56.4 (36.1, 76.7), 35.6 (29.9, 41.3) and 27.6 (15.8, 39.4) (P=0.001, P=0.01, P=0.01, P=0.009, P<0.001 and P=0.008), respectively. Moreover, the extract did not have any significant effects on the other parameters compared to the placebo group at endpoint (P>0.05). No adverse effects were reported.

Side effects and safety of Sage extract powder

Sage herb when used in large amounts causes nervous irritation, convulsions and death. Hence its use is prohibited in known epileptic conditions.

The herb should not be used in pregnancy as chemical compounds like thujone in it may cause uterine stimulation resulting in abortion.

Dosage of Sage extract powder supplement:

Consult your physician if you have any questions about the proper use of Sage extract powder supplements.

Company Information:

Nutragreen Biotechnology Co., Ltd, a brand of Shanghai Lvshang Biotech Co., Ltd, is a GMP compliant and FDA registered manufacturer and supplier of raw materials of plant extracts, botanicals, herbs, especially Tradtional Chinese herbs. Sage extract powder is one of our most competitive ingredients with various specifications and stocks available all year round. You may leave a message below for more detailed information.